Evidence map›Paper›PMID 29101724›Full record

ArticleInternational ophthalmology2018

Adjunctive role of self-retained cryopreserved amniotic membrane in treating immune-related dry eye disease.

Anny M S Cheng, Sean Tighe, Hosam Sheha, Scheffer C G Tseng

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in International ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Biological properties and surgical applications of the human amniotic membrane.Frontiers in bioengineering and biotechnology · 2022
    Review
  11. Article
  12. Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Anny M S ChengHerbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
Sean TigheHerbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
Hosam ShehaHerbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.
Scheffer C G TsengOcular Surface Center, 7000 SW 97th Avenue, Suite 213, Miami, FL, 33173, USA. stseng@ocularsurface.com.

Funding

DEVELOPMENT OF SUTURELESS AMNIOTIC MEMBRANE GRAFTR44EY014768 · NEI · TISSUETECH, INC. · PI TSENG, SCHEFFER C G · 2006 to 2007
$731k
DEVELOPMENT OF SUTURELESS AMNIOTIC MEMBRANE GRAFTR43EY014768 · NEI · TISSUETECH, INC. · PI TSENG, SCHEFFER C G · 2003 to 2003
$103k
National Eye Institute EY014768
6 · The paper itself

Abstract

purposeTo present a case of successful treatment of immune-related severe dry eye disease (DED) by self-retained cryopreserved amniotic membrane (CAM) in conjunction with conventional and systemic immunotherapy. OBSERVATIONS: A 48-year-old female with a 10-year history of rheumatoid arthritis under systemic immunomodulation developed non-resolved severe ocular dryness, pain, photophobia and blurred vision due to corneal epithelial keratopathy OD much worse than OS despite topical artificial tears, steroids, cyclosporine, autologous serum drops, punctal plugs and scleral lens for the last 3 years. During the first year, she received punctal cauterization and a total of 6 CAM, each for an average of 7.2 ± 2.3 days, for recurrent diffuse superficial punctate keratitis (SPK) with filaments to achieve an average symptom-free period of 2.4 ± 0.9 months and visual acuity improvement from 20/400 to 20/200. During the next 2 years, she received surgical closure of puncta for recurrent punctal reopening, additional systemic immunomodulation and a total of 4 CAM, each for an average of 8.5 ± 2 days, for recurrent scattered SPK, to achieve an average symptom-free period of 6.4 ± 1 months and visual acuity improvement from 20/200 to 20/70.

conclusionsSelf-retained CAM can be an adjunctive treatment for immune-related DED, which is refractory to conventional and systemic immunotherapies.

Indexed as

CryopreservationVisual AcuityAmnionAutoimmune DiseasesCyclosporineDry Eye SyndromesFemaleHumansImmunosuppressive AgentsLubricant Eye DropsMiddle AgedCyclosporineImmunosuppressive AgentsLubricant Eye DropsAmniotic membraneAutoimmuneDry eye diseaseOcular surfacePROKERA

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.