Evidence map›Paper›PMID 29101721›Full record

ArticleNeurotoxicity research2018

Restoration of Cognitive Performance in Mice Carrying a Deficient Allele of 8-Oxoguanine DNA Glycosylase by X-ray Irradiation.

Tim Hofer, Nur Duale, Martine Muusse, Dag Marcus Eide, Hildegunn Dahl, Fernando Boix, Jannike M Andersen, Ann Karin Olsen, Oddvar Myhre

Abstract read
PubMed Publisher
In one paragraph

Article in Neurotoxicity research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. DNA Methylation and Establishing Memory.Epigenetics insights · 2022
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Tim HoferDepartment of Toxicology and Risk Assessment, Norwegian Institute of Public Health, PO Box 4404, N-0403, Oslo, Norway.
Nur DualeCentre for Environmental Radioactivity (CERAD CoE), Oslo, Norway.
Martine MuusseDepartment of Toxicology and Risk Assessment, Norwegian Institute of Public Health, PO Box 4404, N-0403, Oslo, Norway.
Dag Marcus EideDepartment of Toxicology and Risk Assessment, Norwegian Institute of Public Health, PO Box 4404, N-0403, Oslo, Norway.
Hildegunn DahlCentre for Environmental Radioactivity (CERAD CoE), Oslo, Norway.
Fernando BoixSection for Drug Abuse Research, Department of Forensic Sciences, Oslo University Hospital, Oslo, Norway.
Jannike M AndersenSection for Drug Abuse Research, Department of Forensic Sciences, Oslo University Hospital, Oslo, Norway.
Ann Karin OlsenCentre for Environmental Radioactivity (CERAD CoE), Oslo, Norway.
Oddvar MyhreDepartment of Toxicology and Risk Assessment, Norwegian Institute of Public Health, PO Box 4404, N-0403, Oslo, Norway. Oddvar.Myhre@fhi.no.ORCID 0000-0002-8635-4699
Norwegian Institute of Public Health · NOOslo University Hospital · NO

Funding

This research was supported by the Norwegian Research Council through the Centre of Excellence CERAD - Centre for Environmental Radioactivity 223268/F50
6 · The paper itself

Abstract

Environmental stressors inducing oxidative stress such as ionizing radiation may influence cognitive function and neuronal plasticity. Recent studies have shown that transgenic mice deficient of DNA glycosylases display unexpected cognitive deficiencies related to changes in gene expression in the hippocampus. The main objectives of the present study were to determine learning and memory performance in C57BL/6NTac 8-oxoguanine DNA glycosylase 1 (Ogg1)

Indexed as

X-Ray TherapyAnalysis of VarianceAnimalsCognition DisordersDisease Models, AnimalDNA GlycosylasesDose-Response Relationship, RadiationGene ExpressionG-Protein-Coupled Receptor Kinase 2Interleukin-1betaMaleMaze LearningMiceMice, Inbred C57BLMice, TransgenicPeroxiredoxin VIDNA GlycosylasesG-Protein-Coupled Receptor Kinase 2GRK2 protein, mouseInterleukin-1betaOgg1 protein, mousePeroxiredoxin VIRNA, Messengeradrenergic receptorbehaviorbraininterleukinknockoutperoxiredoxin

Identifiers

PMID29101721
OpenAlexW2765738373

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.