Evidence map›Paper›PMID 29101652›Full record

ArticleAdvances in experimental medicine and biology2017

Immunology of Gut-Bone Signaling.

Fraser L Collins, Jonathan D Schepper, Naiomy Deliz Rios-Arce, Michael D Steury, Ho Jun Kang, Heather Mallin, Daniel Schoenherr, Glen Camfield, Saima Chishti, Laura R McCabe and 1 more

Abstract read
In one paragraph

Article in Advances in experimental medicine and biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Analysis of the Associations Between the Human Fecal Microbiome and Bone Density, Structure, and Strength: The Osteoporotic Fractures in Men (MrOS) Cohort.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Attenuation of NF-κB in Intestinal Epithelial Cells Is Sufficient to Mitigate the Bone Loss Comorbidity of Experimental Mouse Colitis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019
    Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Fraser L CollinsDepartment of Physiology, Michigan State University, East Lansing, MI, USA.
Jonathan D SchepperDepartment of Physiology, Michigan State University, East Lansing, MI, USA.
Naiomy Deliz Rios-ArceDepartment of Physiology, Michigan State University, East Lansing, MI, USA.
Michael D SteuryDepartment of Physiology, Michigan State University, East Lansing, MI, USA.
Ho Jun KangDepartment of Physiology, Michigan State University, East Lansing, MI, USA.
Heather MallinDepartment of Physiology, Michigan State University, East Lansing, MI, USA.
Daniel SchoenherrDepartment of Physiology, Michigan State University, East Lansing, MI, USA.
Glen CamfieldDepartment of Physiology, Michigan State University, East Lansing, MI, USA.
Saima ChishtiDepartment of Physiology, Michigan State University, East Lansing, MI, USA.
Laura R McCabeDepartment of Physiology and Department of Radiology, Biomedical Imaging Research Centre, Michigan State University, East Lansing, MI, USA. mccabel@msu.edu.
Narayanan ParameswaranDepartment of Physiology, Michigan State University, East Lansing, MI, USA. narap@msu.edu.

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Mechanistic basis of probiotic prevention of osteoporosisR01AT007695 · NCCIH · MICHIGAN STATE UNIVERSITY · PI BRITTON, ROBERT A, MCCABE, LAURA R · 2013 to 2017
$2.2M
GPCR Kinase-2 in TNFalpha Signaling in MacrophagesR01HL095637 · NHLBI · MICHIGAN STATE UNIVERSITY · PI PARAMESWARAN, NARAYANAN · 2009 to 2013
$1.8M
Arrestins in TLR4 Signaling in MacrophagesR01AR056680 · NIAMS · MICHIGAN STATE UNIVERSITY · PI PARAMESWARAN, NARAYANAN · 2009 to 2013
$1.4M
The Role of the Gut and Bone Microenvironment in T1D Bone LossR01DK101050 · NIDDK · MICHIGAN STATE UNIVERSITY · PI MCCABE, LAURA R, PARAMESWARAN, NARAYANAN · 2014 to 2016
$1.1M
GPCR Kinase-5 in Inflammatory Bowel DiseaseR21AI099404 · NIAID · MICHIGAN STATE UNIVERSITY · PI PARAMESWARAN, NARAYANAN · 2013 to 2014
$397k
NCCIH NIH HHS R01 AT007695NHLBI NIH HHS R01 HL095637NIAID NIH HHS R21 AI099404NIAMS NIH HHS R01 AR056680NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK101050
6 · The paper itself

Abstract

In recent years a link between the gastrointestinal tract and bone health has started to gain significant attention. Dysbiosis of the intestinal microbiota has been linked to the pathology of a number of diseases which are associated with bone loss. In addition modulation of the intestinal microbiota with probiotic bacteria has revealed to have both beneficial local and systemic effects. In the present chapter, we discuss the intestinal and bone immune systems, explore how intestinal disease affects the immune system, and examine how these pathologic changes could adversely impact bone health.

Indexed as

AnimalsBone and BonesBone RemodelingCytokinesGastrointestinal TractHumansImmune SystemIntestinal DiseasesLymphocytesSignal TransductionCytokines

Identifiers

PMID29101652
PMCPMC5749247

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.