Evidence map›Paper›PMID 29101646›Full record

ArticleMolecular neurobiology2018

S-Adenosylmethionine Promotes Oxidative Stress and Decreases Na

Ângela Zanatta, Cristiane Cecatto, Rafael Teixeira Ribeiro, Alexandre Umpierrez Amaral, Angela Ts Wyse, Guilhian Leipnitz, Moacir Wajner

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ângela ZanattaPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Cristiane CecattoPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Rafael Teixeira RibeiroPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Alexandre Umpierrez AmaralPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Angela Ts WysePrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Guilhian LeipnitzPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Moacir WajnerPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. mwajner@ufrgs.br.ORCID http://orcid.org/0000-0001-6372-1807
Universidade Federal do Rio Grande do Sul · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 404883/2013-3Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul 2266-2551/14-2Hospital de Clínicas de Porto Alegre 01.06.0842-00Pró-Reitoria de Pesquisa, Universidade Federal do Rio Grande do Sul 27613
6 · The paper itself

Abstract

S-Adenosylmethionine (AdoMet) concentrations are highly elevated in tissues and biological fluids of patients affected by S-adenosylhomocysteine hydrolase deficiency, who are clinically characterized by cerebral symptoms whose pathogenesis is still unknown. In the present work, we investigated the effects of AdoMet on redox homeostasis and on the activity of Na

Indexed as

Oxidative StressAdenosylhomocysteinaseAgingAnimalsAntioxidantsCerebral CortexHomeostasisLipid PeroxidationMalondialdehydeMembrane FluidityOxidation-ReductionProtein CarbonylationRats, WistarS-AdenosylmethionineSodium-Potassium-Exchanging ATPaseSynaptic MembranesAdenosylhomocysteinaseAntioxidantsMalondialdehydeS-AdenosylmethionineSodium-Potassium-Exchanging ATPaseBrain damageNa+, K+-ATPaseRedox homeostasisS-Adenosylhomocysteine hydrolase deficiencyS-Adenosylmethionine

Identifiers

PMID29101646
OpenAlexW2767202402

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.