Evidence map›Paper›PMID 29101610›Full record

ArticleStem cell reviews and reports2018

Endothelial Microparticles are Associated to Pathogenesis of Idiopathic Pulmonary Fibrosis.

Nour C Bacha, Adeline Blandinieres, Elisa Rossi, Nicolas Gendron, Nathalie Nevo, Séverine Lecourt, Coralie L Guerin, Jean Marie Renard, Pascale Gaussem, Eduardo Angles-Cano and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Stem cell reviews and reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Pathological Roles for Endothelial Colony-Forming Cells in Neonatal and Adult Lung Disease.American journal of respiratory cell and molecular biology · 2023
    Review
  9. Human Endothelial Colony-Forming Cells.Cold Spring Harbor perspectives in medicine · 2022
    Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Pathological Insight into 5-HTInternational journal of molecular sciences · 2020
    Review
  16. Review
  17. Review
  18. Review
  19. SHIP-1, a target of miR-155, regulates endothelial cell responses in lung fibrosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nour C BachaInserm UMR-S1140, Paris, France.
Adeline BlandinieresInserm UMR-S1140, Paris, France.
Elisa RossiInserm UMR-S1140, Paris, France.
Nicolas GendronInserm UMR-S1140, Paris, France.
Nathalie NevoInserm UMR-S1140, Paris, France.
Séverine LecourtInserm UMR-S1140, Paris, France.
Coralie L GuerinNational Cytometry Platform, Department of Infection and Immunity, Luxembourg Institute of Health, Luxembourg, France.
Jean Marie RenardSorbonne Paris Cite, Université Paris Descartes, Paris, France.
Pascale GaussemInserm UMR-S1140, Paris, France.
Eduardo Angles-CanoInserm UMR-S1140, Paris, France.
Chantal M BoulangerSorbonne Paris Cite, Université Paris Descartes, Paris, France.
Dominique Israel-BietInserm UMR-S1140, Paris, France.
David M SmadjaInserm UMR-S1140, Paris, France. david.smadja@aphp.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by obliteration of alveolar architecture, resulting in declining lung function and ultimately death. Pathogenic mechanisms remain unclear but involve a concomitant accumulation of scar tissue together with myofibroblasts activation. Microparticles (MPs) have been investigated in several human lung diseases as possible pathogenic elements, prognosis markers and therapeutic targets. We postulated that levels and cellular origins of circulating MPs might serve as biomarkers in IPF patients and/or as active players of fibrogenesis. Flow cytometry analysis showed a higher level of Annexin-V positive endothelial and platelet MPs in 41 IPF patients compared to 22 healthy volunteers. Moreover, in IPF patients with a low diffusing capacity of the lung for carbon monoxide (DL

Indexed as

AgedAged, 80 and overCell-Derived MicroparticlesCell DifferentiationCells, CulturedCollagenEndothelial Progenitor CellsFemaleFibroblastsFlow CytometryHealthy VolunteersHumansIdiopathic Pulmonary FibrosisLungMaleMiddle AgedCollagenUrokinase-Type Plasminogen Activator

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.