ReviewCurrent rheumatology reports2017
Tendon Pathology in Hypercholesterolemia and Familial Hypercholesterolemia.
Review in Current rheumatology reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Metabolic-pathway-based classification of tendinopathy reveals a precise therapeutic strategy targeting chondro-modulatory tenocytes.Bone research · 2026Article
- Rapamycin reduces peritendinous fibrosis but has a limited effect on intratendinous healing in a rodent Achilles tendon injury model.Scientific reports · 2026Article
- Tendon Tissue Engineering: Pathophysiological Mechanism and Bioengineering Therapy of Tendinopathy.International journal of nanomedicine · 2025Review
- Metabolic Syndrome and Tendon Disease: A Comprehensive Review.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Review
- Current Research on the Influence of Statin Treatment on Rotator Cuff Healing.Clinics in orthopedic surgery · 2023Review
- Tendon Disorders in Chronic Liver Disease: A Retrospective Cohort Study in Taiwan.International journal of environmental research and public health · 2023Article
- HDL Cholesterol Efflux and Serum Cholesterol Loading Capacity Alterations Associate to Macrophage Cholesterol Accumulation in FH Patients with Achilles Tendon Xanthoma.International journal of molecular sciences · 2022Article
- Co-Amorphous Formation of Simvastatin-Ezetimibe: Enhanced Physical Stability, Bioavailability and Cholesterol-Lowering Effects in LDLr-/-Mice.Pharmaceutics · 2022Article
- Why Use Adipose-Derived Mesenchymal Stem Cells in Tendinopathic Patients: A Systematic Review.Pharmaceutics · 2022Review
- A lipid metabolite lipidomics assay for prediction and severity evaluation of rotator cuff injury.Frontiers in nutrition · 2022Article
- Dyslipidemia Is Associated With Increased Risk of Achilles Tendon Disorders in Underweight Individuals to a Greater Extent Than Obese Individuals: A Nationwide, Population-Based, Longitudinal Cohort Study.Orthopaedic journal of sports medicine · 2021Article
- Metabolic Regulation of Tendon Inflammation and Healing Following Injury.Current rheumatology reports · 2021Review
- Tendinopathy.Nature reviews. Disease primers · 2021Review
- Saudi Familial Hypercholesterolemia Patients With RareFrontiers in medicine · 2021Article
- Proposal for a Clinical Analysis of Patellar Tendon Pathologies: In Search of Efficient Therapeutic Indications.Orthopaedic journal of sports medicine · 2020Article
- Tendon pathology in hypercholesterolaemia patients: Epidemiology, pathogenesis and management.Journal of orthopaedic translation · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewHypercholesterolemia (HC), or high cholesterol, is usually caused by diet, other health conditions, or inherited diseases, such as familial hypercholesterolemia (FHC). Studies have shown patients with hypercholesterolemia are more prone to tendon injury and impaired healing. Nonetheless, the mechanism by which high cholesterol alters the biochemical and biomechanical properties of tendon and the healing environment is not well defined. This review highlights scientific findings on the relationship between hypercholesterolemia and treatments and tendon pathology at the cellular and tissue level. RECENT
findingsThe release of pro-inflammatory cytokines and upregulation of matrix-degrading proteins in hypercholesterolemic conditions leads to an increase in tendon stiffness and elastic modulus. The effect of hypercholesterolemia drugs, such as statins, on tendon pathology remains unclear. More insight into the relationship between HC and tendon pathology can lead to improved imaging modalities and therapeutics for tendinopathy in hypercholesterolemic patients.
Indexed as
Identifiers
29101577What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.