Evidence map›Paper›PMID 29101530›Full record

ArticleForensic science, medicine, and pathology2017

Sudden death due to malignant hyperthermia with a mutation of RYR1: autopsy, morphology and genetic analysis.

Wenhe Li, Lin Zhang, Yue Liang, Fang Tong, Yiwu Zhou

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Forensic science, medicine, and pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 9 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Wenhe LiDepartment of Forensic Medicine, Tongji Medical College of Huazhong University of Science and Technology, NO.13 Hangkong Road, Wuhan, 430030, People's Republic of China.
Lin ZhangDepartment of Forensic Medicine, Tongji Medical College of Huazhong University of Science and Technology, NO.13 Hangkong Road, Wuhan, 430030, People's Republic of China.
Yue LiangDepartment of Forensic Medicine, Tongji Medical College of Huazhong University of Science and Technology, NO.13 Hangkong Road, Wuhan, 430030, People's Republic of China.
Fang TongDepartment of Forensic Medicine, Tongji Medical College of Huazhong University of Science and Technology, NO.13 Hangkong Road, Wuhan, 430030, People's Republic of China.
Yiwu ZhouDepartment of Forensic Medicine, Tongji Medical College of Huazhong University of Science and Technology, NO.13 Hangkong Road, Wuhan, 430030, People's Republic of China. zhouyiwu@outlook.com.
Huazhong University of Science and Technology · CN

Funding

National Key Research and Development Program of China 2016YFC0800701the Fundamental Research Funds for the Central Universities, HUST No. 2016JCTD117The National Key Research and Development Program of China, National Key Research and Development Program of China National Key Research and Development Program of China
6 · The paper itself

Abstract

Malignant hyperthermia (MH) is an autosomal dominant disorder characterized by abnormal calcium homeostasis in skeletal muscles in response to triggering agents. Autopsy, morphology, and genetic analysis were performed on a 19-year-old man who died rapidly after exposure to sevoflurane during maxillofacial surgery. Muscle spasm around the operation area and limb rigidity occurred and renal tubules full of myoglobin casts were observed by microscopy. Ultrastructural changes in the skeletal muscles and the myocardium were detected by transmission electron microscopy (TEM). Genetic analysis disclosed a ryanodine receptor type 1 (RYR1) gene mutation and a nucleoide mutation in chromosome 19q (G1021A) in the deceased and his father. According to the fore mentioned results, the relationship between the cause of death and MH was confirmed. Thus, genetic analysis can be an important procedure in diagnosing MH.

Indexed as

MutationAmino Acid SubstitutionAnesthetics, InhalationDeath, SuddenGenetic TestingHumansMaleMalignant HyperthermiaMethyl EthersMicroscopy, Electron, TransmissionRyanodine Receptor Calcium Release ChannelSevofluraneYoung AdultAnesthetics, InhalationMethyl EthersRyanodine Receptor Calcium Release ChannelSevofluraneForensic pathologyMalignant hyperthermiaMolecular autopsyMutation of RYR1TEM

Identifiers

PMID29101530
OpenAlexW2765745148

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.