ArticleCalcified tissue international2018
Relationships Between Markers of Inflammation and Muscle Mass, Strength and Function: Findings from the Hertfordshire Cohort Study.
Article in Calcified tissue international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 7 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Resistance training for people with stroke.The Cochrane database of systematic reviews · 2025Pooled it
- Combined cardiorespiratory and resistance training for people with stroke.The Cochrane database of systematic reviews · 2025Pooled it
- Objectively Measured Sedentary Behavior and Physical Fitness in Adults: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- Physical fitness training for stroke patients.The Cochrane database of systematic reviews · 2020Pooled it
- Association of sarcopenic obesity with the risk of all-cause mortality among adults over a broad range of different settings: a updated meta-analysis.BMC geriatrics · 2019Pooled it
- Sarcopenia as a predictor of all-cause mortality among older nursing home residents: a systematic review and meta-analysis.BMJ open · 2018Pooled it
- Sarcopenia as a predictor of hospitalization among older people: a systematic review and meta-analysis.BMC geriatrics · 2018Pooled it
- Effects of Peanut Butter Supplementation on Older Adults' Physical Function: A 6-Month Randomised Controlled Trial.Journal of cachexia, sarcopenia and muscle · 2026Trial
- The Favorable Effects of a High-Intensity Resistance Training on Sarcopenia in Older Community-Dwelling Men with Osteosarcopenia: The Randomized Controlled FrOST Study.Clinical interventions in aging · 2019Trial
- Distinct Proteomic Signatures Driving Progression of Sarcopenia: A Longitudinal Multicohort Study.Journal of cachexia, sarcopenia and muscle · 2026Article
- Latent classes of frailty and their association with intrinsic capacity inolder cancer survivors: A study under the healthy aging paradigm.Global health & medicine · 2026Article
- Association of Sarcopenia with Lower Adiponectin Levels and Reduced Estimated Appendicular Lean Mass in Patients with Metabolic Syndrome: A Cross-Sectional Study.Diseases (Basel, Switzerland) · 2026Article
- Cumulative handgrip strength and trajectories of depressive symptoms in older adults: evidence from two cohort studies.BMC public health · 2025Article
- Inflammaging and the sex-frailty paradox.Aging clinical and experimental research · 2025Article
- Sarcopenia and dynapenia are associated with depression rather than anxiety in Chinese hemodialysis patients.BMC psychiatry · 2025Article
- White Paper on Nutrition Sensing and Ageing.Nutrition bulletin · 2025Article
- Mortality Risk of Sarcopenia and Malnutrition in Older Patients with Type 2 Diabetes Mellitus.Nutrients · 2025Article
- Correlation between iron accumulation and sarcopenia in middle-aged and elderly populations.BMC musculoskeletal disorders · 2025Article
- Association between psoas muscle area and outcomes after transcatheter tricuspid valve repair.Cardiovascular intervention and therapeutics · 2025Article
- Analysis of the diagnostic accuracy of plasma sTNFr-2 concentrations in identifying sarcopenia in community-dwelling older women.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
We investigated the longitudinal relationships between inflammation markers and the following outcomes in a UK cohort study: appendicular lean mass (ALM); walking speed; level and change in grip strength; and sarcopenia defined by the European Working Group on Sarcopenia in Older People. Analyses were based on 336 community-dwelling older men and women (aged 59-70 years) who participated in the Hertfordshire Cohort Study (HCS). Inflammation markers were ascertained at baseline using enzyme-linked immunosorbent assay techniques and Bio-Plex Pro Assays. Grip strength was measured at baseline and follow-up [median follow-up time: 10.8 years (inter-quartile range 10.2-11.6)] and change in grip strength was ascertained using a residual change approach. At follow-up, ALM was ascertained using dual-energy X-ray absorptiometry, customary walking speed was measured and sarcopenia status was ascertained. Gender-adjusted linear and Poisson regression was used to examine the associations between inflammation markers and outcomes with and without adjustment for anthropometric and lifestyle factors. Higher C-reactive protein was associated (p < 0.04) with lower grip strength and accelerated decline in grip strength from baseline to follow-up. Higher cortisol was associated with lower ALM (p < 0.05). Higher interleukin-8 (IL-8) was associated with lower ALM (p < 0.05) and increased risk of sarcopenia [fully-adjusted relative risk per SD increase in IL-8: 1.37 (95% CI 1.10, 1.71), p = 0.005]. All associations were robust in fully-adjusted analyses. Inflammation markers were associated with measures of muscle mass, strength and function in HCS. Further work is required to replicate these associations and to delineate the underlying mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.