Evidence map›Paper›PMID 29101410›Full record

SynthesisOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2018

Dietary vitamin C intake and the risk of hip fracture: a dose-response meta-analysis.

Y Sun, C Liu, Y Bo, J You, Y Zhu, D Duan, H Cui, Q Lu

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 6 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 6 syntheses or guidelines pooled it, 33 citations in OpenAlex.

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  5. Tea consumption and risk of fractures: an updated meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019
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  10. Role of vitamins beyond vitamin DInternational journal of molecular medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Y SunDepartment of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, China.
C LiuThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.
Y BoDepartment of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, China.
J YouDepartment of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, China.
Y ZhuDepartment of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, China.
D DuanDepartment of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, China.
H CuiDepartment of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, China.
Q LuDepartment of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, China. lqjnutr@zzu.edu.cn.
Zhengzhou University · CNFirst Affiliated Hospital of Zhengzhou University · CN

Funding

National Natural Science Foundation of China 81372679National Natural Science Foundation of China 81673165
6 · The paper itself

Abstract

The meta-analysis suggested that dietary vitamin C was statistically inversely associated with the risk of hip fracture (overall OR = 0.73, 95% CI = 0.55-0.97, I

introductionPrevious studies had inconsistent findings regarding the association between vitamin C intake and the risk of hip fracture. Therefore, we conducted a meta-analysis to evaluate the association of dietary vitamin C intake and the risk of hip fracture.

methodsRelevant studies were identified by searching PubMed, Embase, and Web of Science up to December 2016. Additional articles were identified from reviewing the reference lists of relevant articles. The summary relative risks (RRs) or odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by random effects model. Funnel plot and Egger's test were used to test publication bias.

resultsThe total six articles containing 7908 controls and 2899 cases of hip fracture were included in this meta-analysis. By comparing the highest versus the lowest categories of vitamin C intake, we found that dietary vitamin C was statistically correlated with the risk of hip fracture [overall OR = 0.73, 95% CI = 0.55-0.97, I

conclusionsIn conclusion, the results of current meta-analysis strongly support that increasing dietary vitamin C intake can decrease the risk of hip fracture. In order to verify the association of vitamin C intake and hip fracture risk, further well-designed largely randomized controlled trials (RCTs) are needed.

Indexed as

Ascorbic AcidDietDose-Response Relationship, DrugHip FracturesHumansOsteoporotic FracturesPublication BiasRisk AssessmentSensitivity and SpecificityAscorbic AcidAntioxidantDietary vitamin CDose-responseHip fractureMeta-analysis

Identifiers

PMID29101410
OpenAlexW2766548989

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.