ArticleNature communications2017
Autoinhibitory sterol sulfates mediate programmed cell death in a bloom-forming marine diatom.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 70 citations in OpenAlex.
- Article
- Remodeling of the terpenoid metabolism during prolonged phosphate depletion in the marine diatom Phaeodactylum tricornutum.Journal of phycology · 2025Article
- Algal blooms in the ocean: hot spots for chemically mediated microbial interactions.Nature reviews. Microbiology · 2024Review
- Natural Algaecide Sphingosines Identified in Hybrid Straw Decomposition Driven by White-Rot Fungi.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Genome analysis of Parmales, the sister group of diatoms, reveals the evolutionary specialization of diatoms from phago-mixotrophs to photoautotrophs.Communications biology · 2023Article
- Intraspecific variation in metal tolerance modulate competition between two marine diatoms.The ISME journal · 2022Article
- Comparative analysis of full-length mitochondrial genomes of five Skeletonema species reveals conserved genome organization and recent speciation.BMC genomics · 2021Article
- Sulfated and Sulfur-Containing Steroids and Their Pharmacological Profile.Marine drugs · 2021Review
- Biochemical Characterization of a Novel Redox-Regulated Metacaspase in a Marine Diatom.Frontiers in microbiology · 2021Article
- Phytosterol Profiles, Genomes and Enzymes - An Overview.Frontiers in plant science · 2021Review
- Overexpression of Key Sterol Pathway Enzymes in Two Model Marine Diatoms Alters Sterol Profiles inPharmaceuticals (Basel, Switzerland) · 2020Article
- Bioinformatic Characterization of Sulfotransferase Provides New Insights for the Exploitation of Sulfated Polysaccharides inInternational journal of molecular sciences · 2020Article
- New Cytotoxic Cerebrosides from the Red Sea CucumberMarine drugs · 2020Article
- Diatom-Derived Polyunsaturated Aldehydes Are Unlikely to Influence the Microbiota Composition of Laboratory-Cultured Diatoms.Life (Basel, Switzerland) · 2020Article
- Diatom Molecular Research Comes of Age: Model Species for Studying Phytoplankton Biology and Diversity.The Plant cell · 2020Review
- Inhibition of autophagy of Cajal mesenchymal cells by gavage of tong bian decoction based on the rat model of chronic transit constipation.Saudi journal of biological sciences · 2020Article
- Responses of Marine Diatom Skeletonema marinoi to Nutrient Deficiency: Programmed Cell Death.Applied and environmental microbiology · 2020Article
- Algicidal bacteria trigger contrasting responses in model diatom communities of different composition.MicrobiologyOpen · 2019Article
- A widespread alternative squalene epoxidase participates in eukaryote steroid biosynthesis.Nature microbiology · 2019Article
- Metabolism and Biological Activities of 4-Methyl-Sterols.Molecules (Basel, Switzerland) · 2019Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell mortality is a key mechanism that shapes phytoplankton blooms and species dynamics in aquatic environments. Here we show that sterol sulfates (StS) are regulatory molecules of a cell death program in Skeletonema marinoi, a marine diatom-blooming species in temperate coastal waters. The molecules trigger an oxidative burst and production of nitric oxide in a dose-dependent manner. The intracellular level of StS increases with cell ageing and ultimately leads to a mechanism of apoptosis-like death. Disrupting StS biosynthesis by inhibition of the sulfonation step significantly delays the onset of this fatal process and maintains steady growth in algal cells for several days. The autoinhibitory activity of StS demonstrates the functional significance of small metabolites in diatoms. The StS pathway provides another view on cell regulation during bloom dynamics in marine habitats and opens new opportunities for the biochemical control of mass-cultivation of microalgae.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.