ArticleScientific reports2017
Dynamic coupling between slow waves and sleep spindles during slow wave sleep in humans is modulated by functional pre-sleep activation.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Trial
- Phase-Amplitude Coupling of NREM Sleep Oscillations Shows Between-Night Stability and is Related to Overnight Memory Gains.The European journal of neuroscience · 2025Article
- Python/NEURON code for simulating biophysically realistic thalamocortical dynamics during sleep.Software impacts · 2024Article
- Right-lateralized sleep spindles are associated with neutral over emotional bias in picture recognition: An overnight study.Cognitive, affective & behavioral neuroscience · 2023Article
- Functional differences in cerebral activation between slow wave-coupled and uncoupled sleep spindles.Frontiers in neuroscience · 2022Article
- Correlating electroconvulsive therapy response to electroencephalographic markers: Study protocol.Frontiers in psychiatry · 2022Article
- A sleep spindle framework for motor memory consolidation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Sleep spindle density is associated with worry in children with generalized anxiety disorder and healthy controls.Journal of affective disorders · 2020Article
- Dynamics of sleep spindles and coupling to slow oscillations following motor learning in adult mice.Neurobiology of learning and memory · 2019Article
- Large-scale structure and individual fingerprints of locally coupled sleep oscillations.Sleep · 2018Article
- Closed-Loop Targeted Memory Reactivation during Sleep Improves Spatial Navigation.Frontiers in human neuroscience · 2018Article
- Does Sleep Help Prevent Forgetting Rewarded Memory Representations in Children and Adults?Frontiers in psychology · 2018Article
- Local and Widespread Slow Waves in Stable NREM Sleep: Evidence for Distinct Regulation Mechanisms.Frontiers in human neuroscience · 2018Article
- Role of normal sleep and sleep apnea in human memory processing.Nature and science of sleep · 2018Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Co-existent sleep spindles and slow waves have been viewed as a mechanism for offline information processing. Here we explored if the temporal synchronization between slow waves and spindle activity during slow wave sleep (SWS) in humans was modulated by preceding functional activations during pre-sleep learning. We activated differentially the left and right hemisphere before sleep by using a lateralized variant of serial response time task (SRTT) and verified these inter-hemispheric differences by analysing alpha and beta electroencephalographic (EEG) activities during learning. The stability and timing of coupling between positive and negative phases of slow waves and sleep spindle activity during SWS were quantified. Spindle activity was temporally synchronized with both positive (up-state) and negative (down-state) slow half waves. Synchronization of only the fast spindle activity was laterally asymmetric after learning, corresponding to hemisphere-specific activations before sleep. However, the down state was associated with decoupling, whereas the up-state was associated with increased coupling of fast spindle activity over the pre-activated hemisphere. These observations provide original evidence that (1) the temporal grouping of fast spindles by slow waves is a dynamic property of human SWS modulated by functional pre-sleep activation patterns, and (2) fast spindles synchronized by slow waves are functionally distinct.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.