ArticleNature communications2017
Evolutionary genetics of immunological supertypes reveals two faces of the Red Queen.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.
- Meta-analysis of major histocompatibility complex (MHC) class IIA reveals polymorphism and positive selection in many vertebrate species.Molecular ecology · 2022Pooled it
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- Unheralded high MHC class II polymorphism in the abundant Atlantic herring resolved by long-read sequencing.Science advances · 2026Article
- Climate factors and selection shape MHC class II diversity in a montane wild sheep (Ovis ammon).Immunogenetics · 2026Article
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- Allelic diversity ofVeterinary and animal science · 2025Article
- Twenty years of tuberculosis-driven selection shaped the evolution of the meerkat major histocompatibility complex.Nature ecology & evolution · 2025Article
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- In silico prediction method for plant Nucleotide-binding leucine-rich repeat- and pathogen effector interactions.The Plant journal : for cell and molecular biology · 2025Article
- In silico functional analysis of the human, chimpanzee, and gorilla MHC-A repertoires.Immunogenetics · 2025Article
- Structural and evolutionary constraints shape adaptive landscapes of immune-related genes across mammalian phylogeny.PloS one · 2025Article
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- Immunopeptidomics ofBiology · 2024Article
- Eggshell colour differences in a classic example of coevolved eggshell mimicry.Biology letters · 2023Article
- Genetic variation at innate and adaptive immune genes - contrasting patterns of differentiation and local adaptation in a wild gull.Heredity · 2023Article
- Evolution of MHC IIB Diversity Across Cichlid Fish Radiations.Genome biology and evolution · 2023Review
- The impact of HLA polymorphism on herpesvirus infection and disease.Immunogenetics · 2023Review
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- Sequence Diversity and Differences at the Highly Duplicated MHC-I Gene Reflect Viral Susceptibility in Sympatric Pinniped Species.The Journal of heredity · 2022Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 3 countries.
Funding
Abstract
Red Queen host-parasite co-evolution can drive adaptations of immune genes by positive selection that erodes genetic variation (Red Queen arms race) or results in a balanced polymorphism (Red Queen dynamics) and long-term preservation of genetic variation (trans-species polymorphism). These two Red Queen processes are opposite extremes of the co-evolutionary spectrum. Here we show that both Red Queen processes can operate simultaneously by analysing the major histocompatibility complex (MHC) in guppies (Poecilia reticulata and P. obscura) and swamp guppies (Micropoecilia picta). Sub-functionalisation of MHC alleles into 'supertypes' explains how polymorphisms persist during rapid host-parasite co-evolution. Simulations show the maintenance of supertypes as balanced polymorphisms, consistent with Red Queen dynamics, whereas alleles within supertypes are subject to positive selection in a Red Queen arms race. Building on the divergent allele advantage hypothesis, we show that functional aspects of allelic diversity help to elucidate the evolution of polymorphic genes involved in Red Queen co-evolution.
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Registered trials
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