ArticleApplied and environmental microbiology2018
Porcine Small and Large Intestinal Microbiota Rapidly Hydrolyze the Masked Mycotoxin Deoxynivalenol-3-Glucoside and Release Deoxynivalenol in Spiked Batch Cultures
Article in Applied and environmental microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Pooled it
- Modified Mycotoxins in Food: Current Evidence, Key Uncertainties, and Priorities for Risk Assessment.Comprehensive reviews in food science and food safety · 2026Review
- Research progress on the toxicological characteristics and biodegradation of deoxynivalenol and its derivatives.Archives of toxicology · 2026Review
- Article
- Article
- Knowledge structure and evolution of masked mycotoxin research in Sub-Saharan Africa: A systematic review and network analysis approach.Toxicon: X · 2025Review
- Biotransformation of Deoxynivalenol to the Novel Metabolite Deoxynivalenol-8,15-hemiketal-7-glucoside by theACS omega · 2025Article
- A Multi-Year Study of Mycotoxin Co-Occurrence in Wheat and Corn Grown in Ontario, Canada.Toxins · 2024Article
- Article
- Effect of Radium-223 on the Gut Microbiota of Prostate Cancer Patients: A Pilot Case Series Study.Current issues in molecular biology · 2022Article
- Toxicokinetics and metabolism of deoxynivalenol in animals and humans.Archives of toxicology · 2022Review
- Ionizing Radiation from Radiopharmaceuticals and the Human Gut Microbiota: An Ex Vivo Approach.International journal of molecular sciences · 2022Article
- Cellobiose inhibits the release of deoxynivalenol from transformed deoxynivalenol-3-glucoside fromFood chemistry. Molecular sciences · 2022Article
- Exploration of Mycotoxin Accumulation and Transcriptomes of Different Wheat Cultivars duringToxins · 2022Article
- 3-keto-DON, but Not 3-International journal of molecular sciences · 2022Article
- Article
- Article
- Effect of commercially purified deoxynivalenol and zearalenone mycotoxins on microbial diversity of pig cecum contents.Animal bioscience · 2021Article
- Mycotoxin and Gut Microbiota Interactions.Toxins · 2020Review
- Transient effect of single or repeated acute deoxynivalenol and zearalenone dietary challenge on fecal microbiota composition in female finishing pigs.Animal : an international journal of animal bioscience · 2020Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mycotoxin contamination of cereal grains causes well-recognized toxicities in animals and humans, but the fate of plant-bound masked mycotoxins in the gut is less well understood. Masked mycotoxins have been found to be stable under conditions prevailing in the small intestine but are rapidly hydrolyzed by fecal microbiota. This study aims to assess the hydrolysis of the masked mycotoxin deoxynivalenol-3-glucoside (DON3Glc) by the microbiota of different regions of the porcine intestinal tract. Intestinal digesta samples were collected from the jejunum, ileum, cecum, colon, and feces of 5 pigs and immediately frozen under anaerobic conditions. Sample slurries were prepared in M2 culture medium, spiked with DON3Glc or free deoxynivalenol (DON; 2 nmol/ml), and incubated anaerobically for up to 72 h. Mycotoxin concentrations were determined using liquid chromatography-tandem mass spectrometry, and the microbiota composition was determined using a quantitative PCR methodology. The jejunal microbiota hydrolyzed DON3Glc very slowly, while samples from the ileum, cecum, colon, and feces rapidly and efficiently hydrolyzed DON3Glc. No further metabolism of DON was observed in any sample. The microbial load and microbiota composition in the ileum were significantly different from those in the distal intestinal regions, whereas those in the cecum, colon and feces did not differ.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.