ArticleBiology open2018
Insulin regulates multiple signaling pathways leading to monocyte/macrophage chemotaxis into the wound tissue.
Article in Biology open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 45 citations in OpenAlex.
- Efficacy of Microneedle Fractional Radiofrequency Combined With Topical Insulin for the Treatment of Facial Atrophic Acne Scars: A Split-Face, Double-Blinded, Randomized, Placebo-Controlled Trial.Journal of cosmetic dermatology · 2025Trial
- Efficacy of the Novel Formulation of Topical Liothyronine and Liothyronine-insulin in Mild to Moderate Diabetic Foot Ulcer: A Randomized, Triple-blind Clinical Trial.Current medicinal chemistry · 2024Trial
- Insulin Topical Application for Wound Healing in Nondiabetic Patients.Computational and mathematical methods in medicine · 2021Trial
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- Sustained insulin-delivery as a growth factor for modulating oral mucosa healing: A case series.Archives of oral biology · 2026Article
- Insulin-regulated actin dynamics is disrupted in a human keratinocyte model of Hailey-Hailey disease.American journal of physiology. Cell physiology · 2026Article
- Efficacy and safety of microneedling with topical insulin compared with placebo in the treatment of atrophic scars: a prospective study and literature review.Skin health and disease · 2025Article
- Comparing Methods for Induction of Insulin Resistance in Mouse 3T3-L1 Cells.Current diabetes reviews · 2025Article
- Biopolymeric Insulin Membranes for Antimicrobial, Antioxidant, and Wound Healing Applications.Pharmaceutics · 2024Article
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- Anti-inflammatory, procollagen, and wound repair properties of topical insulin gel.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023Article
- The regulatory role of insulin in energy metabolism and leukocyte functions.Journal of leukocyte biology · 2022Review
- Insulin Receptor-Expressing T Cells Appear in Individuals at Risk for Type 1 Diabetes and Can Move into the Pancreas in C57BL/6 Transgenic Mice.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Phosphoproteomic Analysis of Rat Neutrophils Shows the Effect of Intestinal Ischemia/Reperfusion and Preconditioning on Kinases and Phosphatases.International journal of molecular sciences · 2020Article
- Effects of Topical Insulin on Wound Healing: A Review of Animal and Human Evidences.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Review
- Side effects of frequently used oral antidiabetics on wound healing in vitro.Naunyn-Schmiedeberg's archives of pharmacology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Wound healing is a complex process that involves sequential phases that overlap in time and space and affect each other dynamically at the gene and protein levels. We previously showed that insulin accelerates wound healing by stimulating faster and regenerative healing. One of the processes that insulin stimulates is an increase in monocyte/macrophage chemotaxis. In this study, we performed experiments
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.