ArticleEuropean neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology2017
Behavioural and computational methods reveal differential effects for how delayed and rapid onset antidepressants effect decision making in rats.
Article in European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Are biologically meaningful effect sizes a factor in study design? A systematic review of translational chronic variable stress studies.Experimental physiology · 2026Pooled it
- Cognitive Bias Under Adverse and Rewarding Conditions: A Systematic Review of Rodent Studies.Frontiers in behavioral neuroscience · 2020Pooled it
- A core component of psychological therapy causes adaptive changes in computational learning mechanisms.Psychological medicine · 2024Trial
- Preclinical models for evaluating psychedelics in the treatment of major depressive disorder.British journal of pharmacology · 2026Review
- Characterisation of a touchscreen-based task for assessing cognitive judgement bias in mice: a new translational tool for affective state disorder drug screening.Psychopharmacology · 2026Article
- Insight into differing decision-making strategies that underlie cognitively effort-based decision making using computational modeling in rats.Psychopharmacology · 2024Article
- A primer on the use of computational modelling to investigate affective states, affective disorders and animal welfare in non-human animals.Cognitive, affective & behavioral neuroscience · 2024Article
- Investigating neuropsychological and reward-related deficits in a chronic corticosterone-induced model of depression.Psychoneuroendocrinology · 2023Article
- The importance of a multidimensional approach to the preclinical study of major depressive disorder and apathy.Emerging topics in life sciences · 2022Article
- Application of Cognitive Bias Testing in Neuropsychiatric Disorders: A Mini-Review Based on Animal Studies.Frontiers in behavioral neuroscience · 2022Review
- The Acute Pharmacological Manipulation of Dopamine Receptors Modulates Judgment Bias in Japanese Quail.Frontiers in physiology · 2022Article
- Review
- Translational Assessments of Reward Responsiveness in the Marmoset.The international journal of neuropsychopharmacology · 2021Article
- Role of the medial prefrontal cortex in the effects of rapid acting antidepressants on decision-making biases in rodents.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Comparison of acute treatment with delayed-onset versus rapid-acting antidepressants on effort-related choice behaviour.Psychopharmacology · 2020Article
- Rat models of reward deficits in psychiatric disorders.Current opinion in behavioral sciences · 2018Review
- Translational new approaches for investigating mood disorders in rodents and what they may reveal about the underlying neurobiology of major depressive disorder.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Most rats prefer gambling opportunities featuring win-paired cues that drive risky choice: Synergistic interactions between choice of and choice during the cued rat gambling task.Brain and neuroscience advancesArticle
- A systematic review of studies investigating the acute effects ofBrain and neuroscience advancesReview
- Translational Shifts in Preclinical Models of Depression: Implications for Biomarkers for Improved Treatments.Current topics in behavioral neurosciencesArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Major depressive disorder (MDD) is one of the most prevalent psychiatric disorders. Until the recent discovery of the rapid onset antidepressant action of ketamine, pharmacological treatments for MDD were limited to conventional antidepressant drugs with delayed clinical efficacy. Using a judgement bias task, this study has investigated whether the temporal differences observed in patients would be reflected in affective biases and decision making behaviour in rodents. The diffusion model was also used to investigate the underlying decision making processes. Positive biases were induced in this task over timeframes that mirror the rapid versus delayed antidepressant efficacy of the drugs in clinical populations. Diffusion modelling revealed that the antidepressants tested also have different effects on decision making processes, suggesting they may act through different neurobiological substrates. This combination of behaviour and computational modelling may provide a useful approach to further investigate the mechanisms underlying rapid antidepressant effect and assess potential new treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.