Evidence map›Paper›PMID 29100709›Full record

Trial reportVaccine2017

Nutritional status of infants at six months of age following maternal influenza immunization: A randomized placebo-controlled trial in rural Nepal.

Joanne Katz, Janet A Englund, Mark C Steinhoff, Subarna K Khatry, Laxman Shrestha, Jane Kuypers, Luke C Mullany, Helen Y Chu, Steven C LeClerq, Naoko Kozuki and 1 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Vaccine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01034254 (Field Trial of Maternal Influenza Immunization in Asia), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01034254 phase3completednot on this map

Field Trial of Maternal Influenza Immunization in Asia

TypeinterventionalSponsorChildren's Hospital Medical Center, CincinnatiRan2010 to 2017Enrolled3,693ConditionsInfluenza HumanArmsinfluenza vaccine, saline placebo
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Joanne KatzJohns Hopkins Bloomberg School of Public Health, Department of International Health, 615 N. Wolfe Street, Room W5009, Baltimore, MD 21205-2103, USA. Electronic address: jkatz1@jhu.edu.
Janet A EnglundSeattle Children's Hospital and Research Foundation, University of Washington, 4800 Sand Point Way N.E., R5441, Seattle, WA 98105, USA. Electronic address: janet.englund@seattlechildrens.org.
Mark C SteinhoffGlobal Health Center, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC2048, Cincinnati, OH 45229, USA. Electronic address: msteinhoff@gmail.com.
Subarna K KhatryNepal Nutrition Intervention Project - Sarlahi, Kathmandu, Nepal. Electronic address: skhatry@wlink.com.np.
Laxman ShresthaTribhuvan University, Department of Pediatrics and Child Health, Institute of Medicine, Kathmandu, Nepal. Electronic address: laxmanshree12@gmail.com.
Jane KuypersSchool of Medicine, University of Washington, Molecular Virology Laboratory, Suite 320, 1616 Eastlake Ave. E., Seattle, WA 98102, USA. Electronic address: kuypers@u.washington.edu.
Luke C MullanyJohns Hopkins Bloomberg School of Public Health, Department of International Health, 615 N. Wolfe Street, Room W5009, Baltimore, MD 21205-2103, USA. Electronic address: lmullany@gmail.com.
Helen Y ChuUniversity of Washington, Harborview Medical Center, 325 9th Ave, MS 359779, Seattle, WA 98104, USA. Electronic address: helenchu@uw.edu.
Steven C LeClerqJohns Hopkins Bloomberg School of Public Health, Department of International Health, 615 N. Wolfe Street, Room W5009, Baltimore, MD 21205-2103, USA; Nepal Nutrition Intervention Project - Sarlahi, Kathmandu, Nepal. Electronic address: sleclerq@mos.com.np.
Naoko KozukiJohns Hopkins Bloomberg School of Public Health, Department of International Health, 615 N. Wolfe Street, Room W5009, Baltimore, MD 21205-2103, USA. Electronic address: naoko.kozuki@gmail.com.
James M TielschMilken Institute School of Public Health, George Washington University, Department of Global Health, 950 New Hampshire Ave NW, Suite 400, Washington, DC, 20052, USA. Electronic address: jtielsch@email.gwu.edu.
Johns Hopkins University · USUniversity of Washington · USCincinnati Children's Hospital Medical Center · USGeorge Washington University · USTribhuvan University · NP

Funding

Prospective Community-Based Study of RSV Risk Factors in Nepalese ChildrenK23AI103105 · NIAID · UNIVERSITY OF WASHINGTON · PI CHU, HELEN YING-HUI · 2013 to 2017
$897k
NIAID NIH HHS K23 AI103105
6 · The paper itself

Abstract

backgroundMaternal influenza vaccination has increased birth weight in two randomized trials in South Asia but the impact on infant growth is unknown.

methodsA randomized placebo-controlled trial of year round maternal influenza immunization was conducted in two annual cohorts in Sarlahi District, southern plains of Nepal, from April 2011 through April 2014. Infants born to women enrolled in the trial had weight, length, and head circumference measured at birth and 6 months of age. The study was powered for the 3 primary trial outcomes but not for stunting and wasting at 6 months of age.

results3693 women received placebo or influenza vaccine between 17 and 34 weeks gestation, resulting in 3646 live births. About 72% of infants who survived had weight and length measurements between 150 and 210 days of age. Prevalence of stunting (<-2 Z scores length-for-age) was 14.8% in the placebo and 13.6% in the vaccine groups, respectively. Stunting < -3 Z scores was 3.2% versus 2.0% in placebo versus vaccine groups (RR: 0.64 (95% CI: 0.39, 1.04)). Wasting (< -2 Z scores weight for length) was 10.3% versus 11.0% for placebo versus vaccine groups. Severe wasting (< -3 Z scores weight for length) was 3.8% for placebo versus 2.6% for vaccine (RR: 0.69 (95% CI: 0.44, 1.07)). The impact of flu vaccine on wasting was greater in cohort 2 than in cohort 1, (RR: 0.66 (0.44, 0.99) for any wasting), and RR: 0.45 (0.19, 1.09) for severe wasting. This corresponded to a larger impact on birth weight and a better vaccine match with circulating viruses in cohort 2.

conclusionsAlthough maternal immunization reduced low birth weight by 15%, only wasting at 6 months in the 2nd cohort was statistically significantly difference. However, the study was underpowered to detect reductions of public health importance.

trial registrationClinicaltrials.gov (NCT01034254).

Indexed as

Birth WeightNutritional StatusRural PopulationAdultAnthropometryFemaleGrowth DisordersHumansInfantInfant, Low Birth WeightInfant, NewbornInfluenza, HumanInfluenza VaccinesMaleMothersVaccinationInfluenza VaccinesBirthweightEarly infancyMaternal influenza vaccinationSmall for gestational ageStuntingWasting

Identifiers

PMID29100709
PMCPMC5714610
OpenAlexW2765665512

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.