Evidence map›Paper›PMID 29100664›Full record

ArticleAnimal reproduction science2017

Tyrosine hydroxylase in the ventral tegmental area of rams with high or low libido-A role for dopamine.

A C Kramer, A J Mirto, K J Austin, C E Roselli, B M Alexander

Open access · greenAbstract read
In one paragraph

Article in Animal reproduction science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

A C KramerUniversity of Wyoming, Department of Animal Science, Dept 3684, 1000 E. University Ave., Laramie, WY 82071, United States. Electronic address: akramer3@uwyo.edu.
A J MirtoUniversity of Wyoming, Department of Animal Science, Dept 3684, 1000 E. University Ave., Laramie, WY 82071, United States. Electronic address: amirto@uwyo.edu.
K J AustinUniversity of Wyoming, Department of Animal Science, Dept 3684, 1000 E. University Ave., Laramie, WY 82071, United States. Electronic address: kaustin@uwyo.edu.
C E RoselliOregon Health & Science University, Department of Physiology & Pharmacology, 3181 SW Sam Jackson Park Road, Portland, OR 97239, United States. Electronic address: rosellic@ohsu.edu.
B M AlexanderUniversity of Wyoming, Department of Animal Science, Dept 3684, 1000 E. University Ave., Laramie, WY 82071, United States. Electronic address: balex@uwyo.edu.
University of Wyoming · USOregon Health & Science University · US

Funding

A RAM MODEL OF NEUROENDOCRINE FUNCTIONR01RR014270 · NCRR · OREGON HEALTH & SCIENCE UNIVERSITY · PI ROSELLI, CHARLES E. · 2000 to 2011
$5.0M
A Ram Model of Neuroendocrine FunctionR01OD011047 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI ROSELLI, CHARLES E. · 2012 to 2023
$4.8M
NCRR NIH HHS R01 RR014270NIH HHS R01 OD011047
6 · The paper itself

Abstract

Dopamine synthesis in the ventral tegmental area (VTA) is necessary for the reinforcement of sexual behavior. The objective of this study determined if sexual stimuli initiates reward, and whether reward is attenuated in sexually inactive rams. Sexually active rams were exposed to urine from estrous (n=4) or ovariectomized (n=3) ewes with inactive rams (n=3) exposed to urine from estrous ewes. Following exposure, rams were exsanguinated and brains perfused. Alternating sections of the VTA were stained for Fos related antigens (FRA), tyrosine hydroxylase, and dopamine beta-hydroxylase activity. Forebrain tissue, mid-sagittal ventral to the anterior corpus callosum, was stained for dopamine D

Indexed as

AnimalsCells, CulturedDopamineDopamine AgentsFemaleGene Expression Regulation, EnzymologicHydrocortisoneLibidoMaleNeuronsReceptors, Dopamine D2Sexual Behavior, AnimalSheepTyrosine 3-MonooxygenaseVentral Tegmental AreaDopamineDopamine AgentsHydrocortisoneReceptors, Dopamine D2Tyrosine 3-MonooxygenaseRamsReward pathwaySexual behavior

Identifiers

PMID29100664
PMCPMC6659416
OpenAlexW2765256318

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.