ArticleDevelopmental biology2018
Cellular, ultrastructural and molecular analyses of epidermal cell development in the planarian Schmidtea mediterranea.
Article in Developmental biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- Metabolites produced by agat+ cells support regeneration in the planarian Schmidtea mediterranea.Developmental biology · 2026Article
- Unusual inheritance of a functionalScience advances · 2025Article
- Multimodal single cell analyses reveal gene networks of planarian stem cell differentiation.Nature communications · 2025Article
- Article
- DjsoxP-1 and Djsox5 are essential for tissue homeostasis and regeneration in Dugesia japonica.Cell and tissue research · 2025Article
- Stem cells (neoblasts) and positional information jointly dominate regeneration in planarians.Heliyon · 2025Review
- Fibrillarin homologs regulate translation in divergent cell lineages during planarian homeostasis and regeneration.The EMBO journal · 2024Article
- A single-cell atlas of the miracidium larva ofeLife · 2024Article
- A PAK family kinase and the Hippo/Yorkie pathway modulate WNT signaling to functionally integrate body axes during regeneration.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- MRLC controls apoptotic cell death and functions to regulate epidermal development during planarian regeneration and homeostasis.Cell proliferation · 2024Article
- The BAF chromatin remodeling complex licenses planarian stem cells access to ectodermal and mesodermal cell fates.BMC biology · 2023Article
- Chromatin analysis of adult pluripotent stem cells reveals a unique stemness maintenance strategy.Science advances · 2023Article
- Article
- Convergent evolution of a genotoxic stress response in a parasite-specific p53 homolog.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Molecular characterization of a flatworm Girardia isolate from Guanajuato, Mexico.Developmental biology · 2022Article
- Evolutionary Adaptations of Parasitic Flatworms to Different Oxygen Tensions.Antioxidants (Basel, Switzerland) · 2022Review
- Hox genes regulate asexual reproductive behavior and tissue segmentation in adult animals.Nature communications · 2021Article
- Decoding Stem Cells: An Overview on Planarian Stem Cell Heterogeneity and Lineage Progression.Biomolecules · 2021Review
- Planarian Anatomy Ontology: a resource to connect data within and across experimental platforms.Development (Cambridge, England) · 2021Article
- Poly(ADP-Ribose) Polymerase-3 Regulates Regeneration in Planarians.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The epidermis is essential for animal survival, providing both a protective barrier and cellular sensor to external environments. The generally conserved embryonic origin of the epidermis, but the broad morphological and functional diversity of this organ across animals is puzzling. We define the transcriptional regulators underlying epidermal lineage differentiation in the planarian Schmidtea mediterranea, an invertebrate organism that, unlike fruitflies and nematodes, continuously replaces its epidermal cells. We find that Smed-p53, Sox and Pax transcription factors are essential regulators of epidermal homeostasis, and act cooperatively to regulate genes associated with early epidermal precursor cell differentiation, including a tandemly arrayed novel gene family (prog) of secreted proteins. Additionally, we report on the discovery of distinct and previously undescribed secreted organelles whose production is dependent on the transcriptional activity of soxP-3, and which we term Hyman vesicles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.