Evidence map›Paper›PMID 29100594›Full record

ArticleCellular immunology2018

Tumor necrosis factor superfamily member (TNFSF) 13 (APRIL) and TNFSF13B (BAFF) downregulate homeostatic immunoglobulin production in the intestines.

Masaaki Hashiguchi, Yuji Kashiwakura, Yumiko Kanno, Hidefumi Kojima, Tetsuji Kobata

Abstract read
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In one paragraph

Article in Cellular immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Selected Cytokines and Metalloproteinases in Inflammatory Bowel Disease.International journal of molecular sciences · 2023
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Masaaki HashiguchiDepartment of Immunology, Dokkyo Medical University School of Medicine, Japan. Electronic address: mhashi@dokkyomed.ac.jp.
Yuji KashiwakuraDepartment of Immunology, Dokkyo Medical University School of Medicine, Japan.
Yumiko KannoDepartment of Immunology, Dokkyo Medical University School of Medicine, Japan.
Hidefumi KojimaDepartment of Immunology, Dokkyo Medical University School of Medicine, Japan.
Tetsuji KobataDepartment of Immunology, Dokkyo Medical University School of Medicine, Japan.
Dokkyo Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intestinal immunoglobulins (Igs) protect against microbes. However, the regulation of intestinal Ig production is poorly understood. In this study, we have investigated the roles of APRIL (tumor necrosis factor superfamily member [TNFSF] 13) and BAFF (TNFSF13B) in intestinal Ig induction. Peyer's patches (PPs) are, at least in part, an inductive site for Igs, including IgA. Introducing APRIL and BAFF in vivo lowered the frequency of IgG1

Indexed as

AnimalsAntibody FormationB-Cell Activating FactorB-Cell Activation Factor ReceptorB-Cell Maturation AntigenB-LymphocytesDown-RegulationFemaleHomeostasisImmunoglobulin AImmunoglobulin GImmunoglobulinsIntestinesMaleMiceMice, Inbred C57BLB-Cell Activating FactorB-Cell Activation Factor ReceptorB-Cell Maturation AntigenImmunoglobulin AImmunoglobulin GImmunoglobulinsTnfsf13b protein, mouseTnfsf13 protein, mouseTumor Necrosis Factor-alphaTumor Necrosis Factor Ligand Superfamily Member 13APRILBAFFIgAPeyer’s patchTACI

Identifiers

PMID29100594
OpenAlexW2765276218

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.