ArticleBMC biology2017
Characterization of a thalamic nucleus mediating habenula responses to changes in ambient illumination.
Article in BMC biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Ancestral organisation and asymmetric circuit architecture of the habenula revealed in a basal ray-finned fish.Brain structure & function · 2026Article
- Neural circuits for decision-making based on pineal photoreception in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Inhibition mediated by group III metabotropic glutamate receptors regulates habenula activity and defensive behaviors.Nature communications · 2025Article
- On analogies in vertebrate and insect visual systems.Nature reviews. Neuroscience · 2025Review
- Light wavelength modulates search behavior performance in zebrafish.Scientific reports · 2024Article
- Computational modeling of light processing in the habenula and dorsal raphe based on laser ablation of functionally-defined cells.BMC neuroscience · 2024Article
- Diving into the zebrafish brain: exploring neuroscience frontiers with genetic tools, imaging techniques, and behavioral insights.Frontiers in molecular neuroscience · 2024Review
- β-Catenin and SOX2 Interaction Regulate Visual Experience-Dependent Cell Homeostasis in the DevelopingInternational journal of molecular sciences · 2023Article
- Thalamic regulation of a visual critical period and motor behavior.Cell reports · 2023Article
- Ongoing habenular activity is driven by forebrain networks and modulated by olfactory stimuli.Current biology : CB · 2021Article
- Optimized protocol for conditioned place avoidance learning in juvenile zebrafish.STAR protocols · 2021Article
- Contributions of Luminance and Motion to Visual Escape and Habituation in Larval Zebrafish.Frontiers in neural circuits · 2021Article
- Identification of GABAergic neurons innervating the zebrafish lateral habenula.The European journal of neuroscience · 2020Article
- Functional properties of habenular neurons are determined by developmental stage and sequential neurogenesis.Science advances · 2020Article
- Molecular and cellular determinants of motor asymmetry in zebrafish.Nature communications · 2020Article
- Anatomy and Connectivity of the Torus Longitudinalis of the Adult Zebrafish.Frontiers in neural circuits · 2020Article
- Biological Significance of Kisspeptin-Kiss 1 Receptor Signaling in the Habenula of Teleost Species.Frontiers in endocrinology · 2018Review
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5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeural activity in the vertebrate habenula is affected by ambient illumination. The nucleus that links photoreceptor activity with the habenula is not well characterized. Here, we describe the location, inputs and potential function of this nucleus in larval zebrafish.
resultsHigh-speed calcium imaging shows that light ON and OFF both evoke a rapid response in the dorsal left neuropil of the habenula, indicating preferential targeting of this neuropil by afferents conveying information about ambient illumination. Injection of a lipophilic dye into this neuropil led to bilateral labeling of a nucleus in the anterior thalamus that responds to light ON and OFF, and that receives innervation from the retina and pineal organ. Lesioning the neuropil of this thalamic nucleus reduced the habenula response to light ON and OFF. Optogenetic stimulation of the thalamus with channelrhodopsin-2 caused depolarization in the habenula, while manipulation with anion channelrhodopsins inhibited habenula response to light and disrupted climbing and diving evoked by illumination change.
conclusionsA nucleus in the anterior thalamus of larval zebrafish innervates the dorsal left habenula. This nucleus receives input from the retina and pineal, responds to increase and decrease in ambient illumination, enables habenula responses to change in irradiance, and may function in light-evoked vertical migration.
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