Evidence map›Paper›PMID 29100514›Full record

ArticleBMC musculoskeletal disorders2017

Expression of adiponectin in the subchondral bone of lumbar facet joints with different degrees of degeneration.

Qi Lai, Yuan Liu, Leitao Huang, Xuqiang Liu, Xionglong Yu, Qiang Wang, Runsheng Guo, Jianghao Zhu, Hanxiong Cheng, Min Dai and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Anti-Osteoarthritic Mechanisms ofMedicina (Kaunas, Lithuania) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Qi LaiDepartment of Orthopedics, The First Affiliated Hospital of Nanchang University, 17 Yongwai Street, Nangchang, Jiangxi, 330006, China.
Yuan LiuDepartment of Orthopedics, The First Affiliated Hospital of Nanchang University, 17 Yongwai Street, Nangchang, Jiangxi, 330006, China.
Leitao HuangDepartment of Orthopedics, The First Affiliated Hospital of Nanchang University, 17 Yongwai Street, Nangchang, Jiangxi, 330006, China.
Xuqiang LiuDepartment of Orthopedics, The First Affiliated Hospital of Nanchang University, 17 Yongwai Street, Nangchang, Jiangxi, 330006, China.
Xionglong YuDepartment of Orthopedics, The First Affiliated Hospital of Nanchang University, 17 Yongwai Street, Nangchang, Jiangxi, 330006, China.
Qiang WangDepartment of Orthopedics, The First Affiliated Hospital of Nanchang University, 17 Yongwai Street, Nangchang, Jiangxi, 330006, China.
Runsheng GuoDepartment of Orthopedics, The First Affiliated Hospital of Nanchang University, 17 Yongwai Street, Nangchang, Jiangxi, 330006, China.
Jianghao ZhuDepartment of Orthopedics, The First Affiliated Hospital of Nanchang University, 17 Yongwai Street, Nangchang, Jiangxi, 330006, China.
Hanxiong ChengDepartment of Orthopedics, The First Affiliated Hospital of Nanchang University, 17 Yongwai Street, Nangchang, Jiangxi, 330006, China.
Min DaiDepartment of Orthopedics, The First Affiliated Hospital of Nanchang University, 17 Yongwai Street, Nangchang, Jiangxi, 330006, China. 15879177108@163.com.
Bin ZhangDepartment of Orthopedics, The First Affiliated Hospital of Nanchang University, 17 Yongwai Street, Nangchang, Jiangxi, 330006, China. acker11@126.com.ORCID http://orcid.org/0000-0002-5876-1238
Nanchang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOsteoarthritis research has been most commonly performed in the setting of the articular cartilage of the knee. To the best of our knowledge, no studies have evaluated the role of adiponectin in osteoarthritis of the lumbar facet joint (FJOA). Therefore, in this study, we explored whether adiponectin was expressed in the lumbar facet joints and evaluated the role of adiponectin in FJOA.

methodsWe enrolled patients who underwent lumbar computed tomography (CT) and magnetic resonance imaging (MRI) at the Orthopedic Department of the First Affiliated Hospital of Nanchang from May 2015 to June 2016. Lumbar facet joints were obtained from 135 patients at the time of lumbar fusion surgery and divided into three groups according to the Weishaupt grade. Cytokine levels in the subchondral bones were evaluated by enzyme-linked immunosorbent assays (ELISAs), and adiponectin levels were determined by immunohistochemistry, western blotting, and quantitative polymerase chain reaction (qPCR).

resultsBy ELISA, adiponectin levels were examined in the subchondral bone for lumbar facet joint, and adiponectin was found to be negatively correlated with BMI in 52 patients (p < 0.001, r = -0.861). By immunohistochemistry analysis, adiponectin was found to be expressed in the subchondral bone of the lumbar facet, whereas the cartilage area was negative for adiponectin expression. Immunostaining intensity and area was related to the degeneration of the lumbar facet joint, and, in our research, considerably decreased staining intensity and area were observed in more severely degenerated lumbar facet joints. Furthermore, the expression of adiponectin was also reduced in degenerated lumbar facet joints, and the level of decline corresponded to degeneration detected by western blotting and qPCR analysis (n = 27, p < 0.0001).

conclusionsAdiponectin expression was observed in the subchondral bone of the lumbar facet joint and decreased as the degree of degeneration increased. Thus, the results of this study provide new insights into the relationship between adiponectin and osteoarthritis.

Indexed as

AdiponectinAdolescentAdultAgedHumansInterleukin-1betaLeptinLumbar VertebraeMiddle AgedOsteoarthritis, SpineTumor Necrosis Factor-alphaYoung AdultZygapophyseal JointAdiponectinIL1B protein, humanInterleukin-1betaLeptinTumor Necrosis Factor-alphaAdiponectinBone degenerationCartilageFacet jointOsteoarthritisSubchondral bone

Identifiers

PMID29100514
PMCPMC5670694
OpenAlexW2766419051

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.