Evidence map›Paper›PMID 29100357›Full record

ArticleOncotarget2017

DNMT3B overexpression contributes to aberrant DNA methylation and MYC-driven tumor maintenance in T-ALL and Burkitt's lymphoma.

Candace J Poole, Wenli Zheng, Atul Lodh, Aleksey Yevtodiyenko, Daniel Liefwalker, Honglin Li, Dean W Felsher, Jan van Riggelen

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 57 citations in OpenAlex.

  1. Targeting MYC-Driven Cancers: From Oncogenic Addiction to Therapeutic Vulnerability.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Candace J Poole *Augusta University, Department of Biochemistry and Molecular Biology, Augusta, GA 30912, USA.
Wenli Zheng *Augusta University, Department of Biochemistry and Molecular Biology, Augusta, GA 30912, USA.
Atul LodhAugusta University, Department of Biochemistry and Molecular Biology, Augusta, GA 30912, USA.
Aleksey YevtodiyenkoStanford University School of Medicine, Division of Oncology, Departments of Medicine and Pathology, Stanford, CA 94305, USA.
Daniel LiefwalkerStanford University School of Medicine, Division of Oncology, Departments of Medicine and Pathology, Stanford, CA 94305, USA.
Honglin LiAugusta University, Department of Biochemistry and Molecular Biology, Augusta, GA 30912, USA.
Dean W FelsherStanford University School of Medicine, Division of Oncology, Departments of Medicine and Pathology, Stanford, CA 94305, USA.
Jan van RiggelenAugusta University, Department of Biochemistry and Molecular Biology, Augusta, GA 30912, USA.
Augusta University · USStanford University · US

Funding

Essential role of the Ufm1 E3 ligase in intestinal homeostasisR01DK113409 · NIDDK · AUGUSTA UNIVERSITY · PI LI, HONGLIN · 2017 to 2020
$1.4M
NIDDK NIH HHS R01 DK113409
6 · The paper itself

Abstract

Aberrant DNA methylation is a hallmark of cancer. However, our understanding of how tumor cell-specific DNA methylation patterns are established and maintained is limited. Here, we report that in T-cell acute lymphoblastic leukemia (T-ALL) and Burkitt's lymphoma the

Indexed as

DNA methylationDNMT3Bleukemia/lymphomaMYC

Identifiers

PMID29100357
PMCPMC5652751
OpenAlexW2743932745

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.