Evidence map›Paper›PMID 29100287›Full record

ArticleOncotarget2017

Victor Pallarès, Montserrat Hoyos, M Carmen Chillón, Eva Barragán, M Isabel Prieto Conde, Marta Llop, María Virtudes Céspedes, Josep F Nomdedeu, Salut Brunet, Miguel Ángel Sanz and 4 more

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Victor PallarèsBiomedical Research Institute Sant Pau (IIB Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Montserrat HoyosBiomedical Research Institute Sant Pau (IIB Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
M Carmen ChillónDepartment of Hematology, University Hospital of Salamanca and Center of Investigation in Cancer-IBMCC, Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain.
Eva BarragánClinical Laboratory and Department of Hematology, University Hospital La Fe, Valencia, Spain.
M Isabel Prieto CondeDepartment of Hematology, University Hospital of Salamanca and Center of Investigation in Cancer-IBMCC, Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain.
Marta LlopClinical Laboratory and Department of Hematology, University Hospital La Fe, Valencia, Spain.
María Virtudes CéspedesBiomedical Research Institute Sant Pau (IIB Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Josep F NomdedeuDepartment of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Salut BrunetDepartment of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Miguel Ángel SanzClinical Laboratory and Department of Hematology, University Hospital La Fe, Valencia, Spain.
Marcos González-DíazDepartment of Hematology, University Hospital of Salamanca and Center of Investigation in Cancer-IBMCC, Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain.
Jorge SierraDepartment of Hematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Isolda CasanovaBiomedical Research Institute Sant Pau (IIB Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Ramon ManguesBiomedical Research Institute Sant Pau (IIB Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Hospital de Sant Pau · ESBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine · ESCentro de Investigación Biomédica en Red de Cáncer · ESHospital Universitari i Politècnic La Fe · ESInstituto de Investigación Biomédica de Salamanca · ESJosep Carreras Leukaemia Research Institute · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intermediate-risk acute myeloid leukemia (IR-AML) is the largest subgroup of AML patients and is highly heterogeneous. Whereas adverse and favourable risk patients have well-established treatment protocols, IR-AML patients have not. It is, therefore, crucial to find novel factors that stratify this subgroup to implement risk-adapted strategies. The CAS (Crk-associated substrate) adaptor protein family regulates cell proliferation, survival, migration and adhesion. Despite its association with metastatic dissemination and prognosis of different solid tumors, the role of these proteins in hematological malignancies has been scarcely evaluated. Nevertheless, previous work has established an important role for the CAS family members NEDD9 or BCAR1 in the migratory and dissemination capacities of myeloid cells. On this basis, we hypothesized that NEDD9 or BCAR1 expression levels could associate with survival in IR-AML patients and become new prognostic markers. To that purpose, we assessed

Indexed as

acute myeloid leukemiabcar1intermediate-risknedd9prognostic factor

Identifiers

PMID29100287
PMCPMC5652681
OpenAlexW2626896929

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.