ArticleJournal of affective disorders2018
Disrupted engagement of networks supporting hot and cold cognition in remitted major depressive disorder.
Article in Journal of affective disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03977038 (Investigation of Effects of Repetitive Transcranial Magnetic Stimulation), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation of Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on "Hot" and "Cold" Cognitive Systems In Treatment Resistant Depression (TRD)
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Balancing act: Neural correlates of affect dysregulation in youth depression and substance use - A systematic review of functional neuroimaging studies.Developmental cognitive neuroscience · 2020Pooled it
- Changes in brain functional networks in remitted major depressive disorder: a six-month follow-up study.BMC psychiatry · 2023Trial
- Remission is insufficient: predictors and mechanistic models of recurrence in late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Neurophysiological Markers of Regulation Success in Everyday Life in Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Identifying Features of Resilience to Childhood Maltreatment in Resting-State Connectivity Data From Adults With and Without a History of Mood Disorder.Biological psychiatry global open science · 2025Article
- Network analysis of cold cognition and depression in middle-aged and elder population: the moderation of grandparenting.Frontiers in public health · 2023Article
- Negative bias effects during audiovisual emotional processing in major depression disorder.Human brain mapping · 2022Article
- Using Network Parcels and Resting-State Networks to Estimate Correlates of Mood Disorder and Related Research Domain Criteria Constructs of Reward Responsiveness and Inhibitory Control.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Altered functional connectivity in first-episode and recurrent depression: A resting-state functional magnetic resonance imaging study.Frontiers in neurology · 2022Article
- Article
- A Lifespan Model of Interference Resolution and Inhibitory Control: Risk for Depression and Changes with Illness Progression.Neuropsychology review · 2020Review
- Autonomic Nervous System Is Related to Inhibitory and Control Function Through Functional Inter-Region Connectivities of OFC in Major Depression.Neuropsychiatric disease and treatment · 2020Article
- Persistent Intrinsic Functional Network Connectivity Alterations in Middle-Aged and Older Women With Remitted Depression.Frontiers in psychiatry · 2020Article
- Disruption of Neural Homeostasis as a Model of Relapse and Recurrence in Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2019Review
- Implicit affectivity in clinically depressed patients during acute illness and recovery.BMC psychiatry · 2019Article
- Multidimensional imaging techniques for prediction of treatment response in major depressive disorder.Progress in neuro-psychopharmacology & biological psychiatry · 2019Article
- Time in remission from depression predicts cognitive-affective regulation dynamics in everyday life.Journal of clinical and experimental neuropsychologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMajor depressive disorder (MDD) is characterized by dysfunction in cognitive and emotional systems. However, the neural network correlates of cognitive control (cold cognition) and emotion processing (hot cognition) during the remitted state of MDD (rMDD) remain unclear and not fully probed, which has important implications for identifying intermediate phenotypes of depression risk.
methods43 young adults with rMDD and 33 healthy controls (HCs) underwent fMRI while completing separate tasks of cold cognition (Parametric Go/No-Go test) and hot cognition (Facial Emotion Processing Test). Two 2 group (rMDD, HC) × 2 event (sad/fearful faces, correct rejections) factorial models of activation were calculated in SPM8. Functional activation was evaluated in the salience and emotional network (SEN) and the cognitive control network (CCN), including hypothesized interaction between group and task within the CCN.
resultsIndividuals with rMDD demonstrated greater spatial extent of suprathreshold activation within the SEN during sad faces relative to HCs. There were several regions within the CCN in which HCs showed greater activation than rMDD during correct rejections of lures, whereas individuals with rMDD showed greater activation than HCs during sad or fearful faces. LIMITATIONS: Results were not directly compared with active MDD.
conclusionsThese results provide evidence of deficient CCN engagement during cognitive control in rMDD (dysfunctional cold cognition). Elevated SEN activation during sad faces could represent heightened salience of negative emotional faces in rMDD; elevated CCN activation during emotional faces in rMDD could represent compensatory regulatory control. These group differences may represent vulnerability factors, scars of prior depressive episodes, or processes maintaining wellness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.