Evidence map›Paper›PMID 29099935›Full record

ArticleThe Journal of infectious diseases2018

Immunoglobulin Attenuates Streptokinase-Mediated Virulence in Streptococcus dysgalactiae Subspecies equisimilis Necrotizing Fasciitis.

Federica Andreoni, Fabio Ugolini, Nadia Keller, Andrina Neff, Victor Nizet, Andrew Hollands, Ewerton Marques Maggio, Annelies S Zinkernagel, Reto A Schuepbach

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Clinical microbiology reviews · 2024
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Federica AndreoniDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Switzerland.
Fabio UgoliniInstitute of Intensive Care Medicine, University Hospital Zurich, University of Zurich, Switzerland.
Nadia KellerDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Switzerland.
Andrina NeffDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Switzerland.
Victor NizetDepartment of Pediatrics, Division of Pharmacology and Drug Discovery, San Diego, California.
Andrew HollandsDepartment of Pediatrics, Division of Pharmacology and Drug Discovery, San Diego, California.
Ewerton Marques MaggioDepartment of Pathology and Molecular Pathology, University Hospital Zurich, University of Zurich, Switzerland.
Annelies S ZinkernagelDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Switzerland.
Reto A SchuepbachInstitute of Intensive Care Medicine, University Hospital Zurich, University of Zurich, Switzerland.

Funding

GAS Switch from Colonizing Bacterium to Invasive PathogenR01AI077780 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIZET, VICTOR · 2008 to 2019
$3.8M
NIAID NIH HHS R01 AI077780
6 · The paper itself

Abstract

Background: Necrotizing fasciitis (NF) retains a very high mortality rate despite prompt and adequate antibiotic treatment and surgical debridement. Necrotizing fasciitis has recently been associated with Streptococcus dysgalactiae subspecies equisimilis (SDSE). Methods: We investigated the causes of a very severe clinical manifestation of SDSE-NF by assessing both host and pathogen factors. Results: We found a lack of streptokinase-function blocking antibodies in the patient resulting in increased streptokinase-mediated fibrinolysis and bacterial spread. At the same time, the clinical SDSE isolate produced very high levels of streptokinase. Exogenous immunoglobulin Gs (ex-IgGs) efficiently blocked streptokinase-mediated fibrinolysis in vitro, indicating a protective role against the action of streptokinase. In vivo, SDSE infection severity was also attenuated by ex-IgGs in a NF mouse model. Conclusions: These findings illustrate for the first time that the lack of specific antibodies against streptococcal virulence factors, such as streptokinase, may contribute to NF disease severity. This can be counteracted by ex-IgGs.

Indexed as

AdultAnimalsAntibodies, BacterialFasciitis, NecrotizingFemaleFibrinolytic AgentsHost-Pathogen InteractionsHumansMice, Inbred C57BLStreptococcal InfectionsStreptococcusStreptokinaseVirulence FactorsAntibodies, BacterialFibrinolytic AgentsStreptokinaseVirulence Factorsbacterial spreadingfibrinolysisnecrotizing fasciitispooled human immunoglobulinStreptococcus dysgalactiae subspecies equisimilisstreptokinase

Identifiers

PMID29099935
PMCPMC7263839

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.