Evidence map›Paper›PMID 29099810›Full record

ReviewInternational journal of molecular sciences2017

Estrogen Effects on Wound Healing.

Huann-Cheng Horng, Wen-Hsun Chang, Chang-Ching Yeh, Ben-Shian Huang, Chia-Pei Chang, Yi-Jen Chen, Kuan-Hao Tsui, Peng-Hui Wang

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 4 pooled it
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 4 syntheses or guidelines pooled it, 192 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Menopause and skin.Menopause (New York, N.Y.) · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Loss of MFAP5 and Its Effect on Skin Homeostasis and Wound Healing.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  17. Review
  18. Toward Sex-Specific Biomaterials Innovation: A Perspective.ACS biomaterials science & engineering · 2025
    Review
  19. Review
  20. Review

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Huann-Cheng HorngDepartment of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. hchorng@vghtpe.gov.tw.
Wen-Hsun ChangDepartment of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. whchang@vghtpe.gov.tw.
Chang-Ching YehDepartment of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. ccyeh39@gmail.com.
Ben-Shian HuangDepartment of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. benshianhuang@gmail.com.
Chia-Pei ChangDepartment of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. jpchang2@vghtpe.gov.tw.
Yi-Jen ChenDepartment of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. chenyj@vghtpe.gov.tw.
Kuan-Hao TsuiDepartment of Obstetrics and Gynecology, National Yang-Ming University, Taipei 112, Taiwan. khtsui60@gmail.com.
Peng-Hui WangDepartment of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. phwang@vghtpe.gov.tw.ORCID 0000-0002-6048-8541
National Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wound healing is a physiological process, involving three successive and overlapping phases-hemostasis/inflammation, proliferation, and remodeling-to maintain the integrity of skin after trauma, either by accident or by procedure. Any disruption or unbalanced distribution of these processes might result in abnormal wound healing. Many molecular and clinical data support the effects of estrogen on normal skin homeostasis and wound healing. Estrogen deficiency, for example in postmenopausal women, is detrimental to wound healing processes, notably inflammation and re-granulation, while exogenous estrogen treatment may reverse these effects. Understanding the role of estrogen on skin might provide further opportunities to develop estrogen-related therapy for assistance in wound healing.

Indexed as

Signal TransductionWound HealingAnimalsCell ProliferationDrug DiscoveryEstrogensHemostasisHumansInflammationReceptors, EstrogenEstrogensReceptors, Estrogenestrogenestrogen receptorwound healing

Identifiers

PMID29099810
PMCPMC5713294
OpenAlexW2765643716

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.