ReviewVaccines2017
Impact of the Respiratory Microbiome on Host Responses to Respiratory Viral Infection.
Review in Vaccines, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Microbiota profiles in pre-school children with respiratory infections: Modifications induced by the oral bacterial lysate OM-85.Frontiers in cellular and infection microbiology · 2022Trial
- Beyond Pathogens: Modulating the Commensal Microbiota to Reshape Immunity for Respiratory Disease Intervention.Pathogens (Basel, Switzerland) · 2026Review
- Lung Microbiome Diversity, Infection Dynamics, and Microbe-Mediated Cross-Protection.MicrobiologyOpen · 2026Review
- Distinct host-pathogen and microbiome responses of aoudad (Ammotragus lervia) and bighorn sheep (Ovis canadensis) following exposure to Mycoplasma ovipneumoniae with or without co-exposure to leukotoxigenic Pasteurellaceae.BMC veterinary research · 2026Article
- The intersection between human metapneumovirus and the respiratory microbiome.Virology journal · 2025Review
- Impact of seasonal variation on the oral and nasopharyngeal microbiome in school-aged children: the school MicroBE initiative.mSystems · 2025Article
- Review
- A bibliometric analysis of m6A methylation in viral infection from 2000 to 2022.Virology journal · 2024Article
- Bacterial Biomarkers of the Oropharyngeal and Oral Cavity during SARS-CoV-2 Infection.Microorganisms · 2023Article
- Analysis of respiratory virus detection in hospitalized children with acute respiratory infection during the COVID-19 pandemic.Virology journal · 2023Article
- Microbiota composition in the lower respiratory tract is associated with severity in patients with acute respiratory distress by influenza.Virology journal · 2023Article
- Article
- Age-Related Changes in the Nasopharyngeal Microbiome Are Associated With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and Symptoms Among Children, Adolescents, and Young Adults.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Alterations in the nasopharyngeal microbiome associated with SARS-CoV-2 infection status and disease severity.PloS one · 2022Article
- Mild and Severe SARS-CoV-2 Infection Induces Respiratory and Intestinal Microbiome Changes in the K18-hACE2 Transgenic Mouse Model.Microbiology spectrum · 2021Article
- miR-200c-3p upregulation and ACE2 downregulation via bacterial LPS and LTA as interesting aspects for COVID-19 treatment and immunity.Molecular biology reports · 2021Article
- Dysbiosis in Pediatrics Is Associated with Respiratory Infections: Is There a Place for Bacterial-Derived Products?Microorganisms · 2021Review
- The Chemokine CCL5 Inhibits the Replication of Influenza A Virus Through SAMHD1 Modulation.Frontiers in cellular and infection microbiology · 2021Article
- Impact of the Gastro-Intestinal Bacterial Microbiome onHealthcare (Basel, Switzerland) · 2019Review
- Lung inflammation and disease: A perspective on microbial homeostasis and metabolism.IUBMB life · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Viruses are responsible for most of both upper and lower acute respiratory infections (ARIs). The microbiome-the ecological community of microorganisms sharing the body space, which has gained considerable interest over the last decade-is modified in health and disease states. Even if most of these disturbances have been previously described in relation to chronic disorders of the gastrointestinal microbiome, after a short reminder of microbiome characteristics and methods of characterization, this review will describe the impact of the microbiome (mainly respiratory) on host responses to viral ARIs. The microbiome has a direct environmental impact on the host cells but also an indirect impact on the immune system, by enhancing innate or adaptive immune responses. In microbial infections, especially in viral infections, these dramatic modifications could lead to a dramatic impact responsible for severe clinical outcomes. Studies focusing on the microbiome associated with transcriptomic analyses of the host response and deep characterization of the pathogen would lead to a better understanding of viral pathogenesis and open avenues for biomarker development and innovative therapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.