Evidence map›Paper›PMID 29099754›Full record

ArticleGenes2017

RNAi-Mediated Specific Gene Silencing as a Tool for the Discovery of New Drug Targets in Giardia lamblia; Evaluation Using the NADH Oxidase Gene.

Jaime Marcial-Quino, Saúl Gómez-Manzo, Francisco Fierro, Yadira Rufino-González, Daniel Ortega-Cuellar, Edgar Sierra-Palacios, America Vanoye-Carlo, Abigail González-Valdez, Angélica Torres-Arroyo, Jesús Oria-Hernández and 1 more

Open access · goldAbstract read
In one paragraph

Article in Genes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Jaime Marcial-QuinoCONACYT-Instituto Nacional de Pediatría, Secretaría de Salud, Ciudad de México 04530, Mexico. jmarcialqu@conacyt.mx.
Saúl Gómez-ManzoLaboratorio de Bioquímica Genética, Instituto Nacional de Pediatría, Secretaría de Salud, Ciudad de México 04530, Mexico. saulmanzo@ciencias.unam.mx.ORCID 0000-0003-2095-9182
Francisco FierroDepartamento de Biotecnología, Universidad Autónoma Metropolitana, Iztapalapa 09340, Mexico. degfff@yahoo.com.ORCID 0000-0002-2582-5362
Yadira Rufino-GonzálezLaboratorio de Parasitología Experimental, Instituto Nacional de Pediatría, Secretaría de Salud, Ciudad de México 04530, Mexico. yadirg@gmail.com.
Daniel Ortega-CuellarLaboratorio de Nutrición Experimental, Instituto Nacional de Pediatría, Secretaría de Salud, Ciudad de México 04530, Mexico. dortegadan@gmail.com.ORCID 0000-0001-7950-4911
Edgar Sierra-PalaciosColegio de Ciencias y Humanidades, Plantel Casa Libertad, Universidad Autónoma de la Ciudad de México, Ciudad de México 09620, Mexico. edgar.sierra@uacm.edu.mx.
America Vanoye-CarloLaboratorio de Neurociencias, Instituto Nacional de Pediatría, Secretaría de Salud, Ciudad de México 04530, Mexico. america_vc@yahoo.com.mx.
Abigail González-ValdezDepartamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México 04530, Mexico. abigaila@correo.biomedicas.unam.mx.
Angélica Torres-ArroyoLaboratorio de Bioquímica Genética, Instituto Nacional de Pediatría, Secretaría de Salud, Ciudad de México 04530, Mexico. angelica.tarroyo@gmail.com.
Jesús Oria-HernándezLaboratorio de Bioquímica Genética, Instituto Nacional de Pediatría, Secretaría de Salud, Ciudad de México 04530, Mexico. jesus.oria.inp@gmail.com.
Horacio Reyes-VivasLaboratorio de Bioquímica Genética, Instituto Nacional de Pediatría, Secretaría de Salud, Ciudad de México 04530, Mexico. hreyesvivas@yahoo.com.mx.
Secretaria de Salud · MXUniversidad Autónoma de la Ciudad de México · MXUniversidad Autónoma Metropolitana · MXUniversidad Nacional Autónoma de México · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The microaerophilic protozoan

Indexed as

drug targetsGiardiaNADH oxidaseRNAisiRNAstem-loop RT-qPCR

Identifiers

PMID29099754
PMCPMC5704216
OpenAlexW2766957087

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.