Evidence map›Paper›PMID 29099606›Full record

ArticleAmerican journal of respiratory and critical care medicine2018

Comparison of Nutrition and Lung Function Outcomes in Patients with Cystic Fibrosis Living in Canada and the United States.

Christopher H Goss, Jenna Sykes, Sanja Stanojevic, Bruce Marshall, Kristofer Petren, Josh Ostrenga, Aliza Fink, Alexander Elbert, Bradley S Quon, Anne L Stephenson

Abstract readComparative Study
In one paragraph

Article in American journal of respiratory and critical care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Use of elexacaftor+tezacaftor+ivacaftor in individuals with cystic fibrosis and at least one F508del allele: a systematic review and meta-analysis.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2024
    Pooled it
  2. Guideline
  3. Article
  4. Review
  5. Article
  6. Socioeconomic burden of cystic fibrosis in Canada.BMJ open respiratory research · 2024
    Article
  7. Article
  8. Quality of anthropometric data measured in children and adolescents with cystic fibrosis: a scoping review.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2023
    Article
  9. Article
  10. Body Mass Index Recovery after Lung Transplant for Cystic Fibrosis.Annals of the American Thoracic Society · 2022
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. The future of cystic fibrosis care: a global perspective.The Lancet. Respiratory medicine · 2020
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Christopher H Goss1 Division of Pulmonary and Critical Care Medicine, Department of Medicine and Pediatrics, University of Washington Medical Center, Seattle, Washington.
Jenna Sykes2 Department of Respirology, St. Michael's Hospital, Toronto, Ontario, Canada.
Sanja Stanojevic3 Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Bruce Marshall5 Cystic Fibrosis Foundation, Bethesda, Maryland.
Kristofer Petren5 Cystic Fibrosis Foundation, Bethesda, Maryland.
Josh Ostrenga5 Cystic Fibrosis Foundation, Bethesda, Maryland.
Aliza Fink5 Cystic Fibrosis Foundation, Bethesda, Maryland.
Alexander Elbert5 Cystic Fibrosis Foundation, Bethesda, Maryland.
Bradley S Quon6 Centre for Heart Lung Innovation, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Anne L Stephenson2 Department of Respirology, St. Michael's Hospital, Toronto, Ontario, Canada.

Funding

Transform Dissemination and Implementation Science in CTSA ProgramsUL1TR002319 · NCATS · UNIVERSITY OF WASHINGTON · PI John K. Amory · 2017 to 2026
$100.0M
Institute of Translational Health SciencesUL1TR000423 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$49.4M
Translational Research Center to Expedite Novel Therapies in Cystic FibrosisP30DK089507 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI Christopher Hooper Goss, Lucas R Hoffman · 2010 to 2026
$21.4M
Investigating treatment resistance mechanisms in chronic bacterial infectionsR01AI101307 · NIAID · UNIVERSITY OF WASHINGTON · PI BRUCE, JAMES EDWARD, MANOIL, COLIN · 2012 to 2016
$2.9M
Regulation of host inflammatory responses and outcome in melioidosis by TLR5R01HL113382 · NHLBI · UNIVERSITY OF WASHINGTON · PI WEST, TIMOTHY EOIN · 2012 to 2016
$2.6M
Phase 2 Study of Intravenous Gallium Nitrate in the Treatment of Cystic FibrosisR01FD003704 · FDA · UNIVERSITY OF WASHINGTON · PI GOSS, CHRISTOPHER HOOPER · 2009 to 2018
$2.0M
FDA HHS R01 FD003704NCATS NIH HHS UL1 TR000423NCATS NIH HHS UL1 TR002319NHLBI NIH HHS R01 HL113382NIAID NIH HHS R01 AI101307NIDDK NIH HHS P30 DK089507
6 · The paper itself

Abstract

rationaleA 10-year gap in the median age of survival for patients with cystic fibrosis (CF) was reported between patients living in Canada compared with patients living in the United States.

objectivesBecause both malnutrition and poor lung function are associated with an increased risk of mortality in CF, we investigated the temporal and longitudinal trends in lung function and nutrition between Canada and the United States.

methodsThis cohort study used Canadian CF Registry and U.S. CF Foundation Patient Registry data from 1990 to 2013. A unified dataset was created to harmonize the variables collected within the two registries for the purpose of comparing outcomes between the two countries. MEASUREMENTS AND MAIN

resultsWe conducted three analyses: survival differences by birth cohort; population trends for FEV

conclusionsThe reasons for the observed improvements, and catch-up in the United States, are likely multifactorial and include the introduction of high-fat, high-calorie diets; introduction of newborn screening; and/or improved access to care for CF children in the United States.

Indexed as

AdolescentAdultAgedAged, 80 and overAge FactorsCanadaChildChild, PreschoolCohort StudiesCystic FibrosisFemaleHumansInfantInfant, NewbornLungMalecystic fibrosisinternational comparisonlung functionnutritionsurvival

Identifiers

PMID29099606
PMCPMC5855073

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.