Evidence map›Paper›PMID 29099578›Full record

ArticleACS chemical neuroscience2018

Development of a Positron Emission Tomography Radiotracer for Imaging Elevated Levels of Superoxide in Neuroinflammation.

Catherine Hou, Chia-Ju Hsieh, Shihong Li, Hsiaoju Lee, Thomas J Graham, Kuiying Xu, Chi-Chang Weng, Robert K Doot, Wenhua Chu, Subhasish K Chakraborty and 3 more

Abstract read
In one paragraph

Article in ACS chemical neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Article
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  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. PET Imaging with [Antioxidants (Basel, Switzerland) · 2024
    Article
  13. Oxidative Stress and Age-Related Tumors.Antioxidants (Basel, Switzerland) · 2024
    Review
  14. Ten "Cheat Codes" for Measuring Oxidative Stress in Humans.Antioxidants (Basel, Switzerland) · 2024
    Review
  15. Positron Emission Tomography with [International journal of molecular sciences · 2024
    Article
  16. Review
  17. [Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022
    Article
  18. [EJNMMI research · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Catherine HouDepartment of Radiology, Perelman School of Medicine , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.ORCID 0000-0001-8905-8492
Chia-Ju HsiehDepartment of Radiology, Perelman School of Medicine , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.
Shihong LiDepartment of Radiology, Perelman School of Medicine , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.
Hsiaoju LeeDepartment of Radiology, Perelman School of Medicine , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.
Thomas J GrahamDepartment of Radiology, Perelman School of Medicine , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.
Kuiying XuDepartment of Radiology, Perelman School of Medicine , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.
Chi-Chang WengDepartment of Radiology, Perelman School of Medicine , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.
Robert K DootDepartment of Radiology, Perelman School of Medicine , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.
Wenhua ChuMallinckrodt Institute of Radiology , Washington University School of Medicine , St. Louis , Missouri 63110-1016 , United States.
Subhasish K ChakrabortyDepartment of Medicine , Vanderbilt University School of Medicine , Nashville , Tennessee 37232 , United States.
Laura L DuganDepartment of Medicine , Vanderbilt University School of Medicine , Nashville , Tennessee 37232 , United States.
Mark A MintunMallinckrodt Institute of Radiology , Washington University School of Medicine , St. Louis , Missouri 63110-1016 , United States.
Robert H MachDepartment of Radiology, Perelman School of Medicine , University of Pennsylvania , Philadelphia , Pennsylvania 19104 , United States.ORCID 0000-0002-7645-2869

Funding

Systemic Inflammation and Central Nervous System DysfunctionR01AG033679 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DUGAN, LAURA L · 2010 to 2014
$1.6M
NIA NIH HHS R01 AG033679
6 · The paper itself

Abstract

Reactive oxygen species (ROS) are believed to play a major role in the proinflammatory, M1-polarized form of neuroinflammation. However, it has been difficult to assess the role of ROS and their role in neuroinflammation in animal models of disease because of the absence of probes capable of measuring their presence with the functional imaging technique positron emission tomography (PET). This study describes the synthesis and in vivo evaluation of [

Indexed as

Positron-Emission TomographyAnimalsBrainDisease Models, AnimalFluorine RadioisotopesInflammationMiceRadiopharmaceuticalsReactive Oxygen SpeciesSuperoxidesTissue DistributionFluorine RadioisotopesRadiopharmaceuticalsReactive Oxygen SpeciesSuperoxidesNeuroinflammationPositron emission tomographyReactive oxygen speciesSuperoxide

Identifiers

PMID29099578
PMCPMC5865080

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.