ArticleEpigenetics2017
Variability of genome-wide DNA methylation and mRNA expression profiles in reproductive and endocrine disease related tissues.
Article in Epigenetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review on the DNA methylation role in endometriosis: current evidence and perspectives.Clinical epigenetics · 2025Pooled it
- Predicting Endometriosis Status and Menstrual Cycle Phase Using DNA Methylation.bioRxiv : the preprint server for biology · 2026Article
- Endometriosis risk factors and comorbidities by endometriosis lesion macrophenotypes: an analysis from the What is Endometriosis (WisE) study.American journal of obstetrics and gynecology · 2026Article
- TCM Treatment of Endometriosis: Pathogenesis, Mechanism and Clinical Practice.Drug design, development and therapy · 2026Review
- Non-Invasive Methods for Early Diagnosis of Endometriosis-A Comprehensive Narrative Literature Review.Healthcare (Basel, Switzerland) · 2025Review
- Methylation Risk Score Modelling in Endometriosis: Evidence for Non-Genetic DNA Methylation Effects in a Case-Control Study.International journal of molecular sciences · 2025Article
- Exploring the value of a well-established conditioned pain modulation paradigm in women: a Translational Research in Pelvic Pain (TRiPP) study.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Circulating inflammatory biomarkers and endometriosis lesion characteristics in the WisE consortium.npj women's health · 2025Article
- The Different Gene Expression Profile in the Eutopic and Ectopic Endometrium Sheds New Light on the Endometrial Seed in Endometriosis.Biomedicines · 2024Review
- A Systematic Review of Epigenetics of Endometriosis.F&S reviews · 2024Article
- Endometriosis in the era of precision medicine and impact on sexual and reproductive health across the lifespan and in diverse populations.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023Review
- Global endometrial DNA methylation analysis reveals insights into mQTL regulation and associated endometriosis disease risk and endometrial function.Communications biology · 2023Article
- New concepts on the etiology of endometriosis.The journal of obstetrics and gynaecology research · 2023Article
- The DNA demethylation-regulated SFRP2 dictates the progression of endometriosis via activation of the Wnt/β-catenin signaling pathway.BMC molecular and cell biology · 2023Article
- Article
- Epigenetic age provides insight into tissue origin in endometriosis.Scientific reports · 2022Article
- Genetic Regulation of Transcription in the Endometrium in Health and Disease.Frontiers in reproductive health · 2021Review
- Bisphenol A in utero exposure induces ovary dysfunction in mice offspring and the ameliorating effects of Cuscuta chinensis flavonoids.Environmental science and pollution research international · 2020Article
- Molecular signature of eutopic endometrium in endometriosis based on the multi-omics integrative synthesis.Journal of assisted reproduction and genetics · 2020Article
- Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Genome-wide association studies in the fields of reproductive medicine and endocrinology are yielding robust genetic variants associated with disease. Integrated genomic, transcriptomic, and epigenomic molecular profiling studies are common methodologies used to understand the biologic pathways perturbed by these variants. However, molecular profiling resources do not include the tissue most relevant to many female reproductive traits, the endometrium, while the parameters influencing variability of results from its molecular profiling are unclear. We investigated the sources of DNA methylation and RNA expression profile variability in endometrium (n = 135), endometriotic disease tissue (endometriosis), and subcutaneous abdominal fat samples from 24 women, quantifying between-individual, within-tissue (cellular heterogeneity), and technical variation. DNA samples (n = 96) were analyzed using Illumina HumanMethlylation450 BeadChip arrays; RNA samples (n = 39) were analyzed using H12-expression arrays. Variance-component analyses showed that, for the top 10-50% variable DNA methylation/RNA expression sites, between-individual variation far exceeded within-tissue and technical variation. Menstrual-phase accounted for most variability in methylation/expression patterns in endometrium (P
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.