ArticleJournal of the American Chemical Society2017
Chemoselective Intermolecular Cross-Enolate-Type Coupling of Amides.
Article in Journal of the American Chemical Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Enantioselective synthesis of β-aryl-β-acyl esters as unsymmetrical 1,4-dicarbonyl compoundsChemical science · 2026Article
- α-Amido Sulfonium Salts Provide a Platform for Photocatalytic Metal-Free Carbon-Carbon Bond Formation in Amides.ACS catalysis · 2025Article
- General Synthesis of 2-Substituted Benzoxazoles Based on TfMolecules (Basel, Switzerland) · 2025Article
- Stereoselective Synthesis of 1,n-Dicarbonyl Compounds Through Palladium-Catalyzed Ring Opening/Isomerization of Densely Substituted Cyclopropanols.Angewandte Chemie (International ed. in English) · 2025Article
- Catalytic Enantioselective Synthesis of 1,4-(Hetero) Dicarbonyl Compounds through α-Carbonyl Umpolung.Journal of the American Chemical Society · 2025Article
- Article
- New Strategies for the Functionalization of Carbonyl Derivatives via α-Umpolung: From Enolates to Enolonium Ions.Accounts of chemical research · 2023Article
- Synthesis of Aminoalkyl Sclareolide Derivatives and Antifungal Activity Studies.Molecules (Basel, Switzerland) · 2023Article
- Hypervalent iodine-promoted twofold oxidative coupling of amines with amides and thioamides: chemoselective pathway to oxazoles and thiazoles.Chemical science · 2023Article
- Challenges and Breakthroughs in Selective Amide Activation.Angewandte Chemie (International ed. in English) · 2022Review
- Challenges and Breakthroughs in Selective Amide Activation.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2022Review
- Sulfur(iv)-mediated umpolung α-heterofunctionalization of 2-oxazolines.Chemical science · 2022Article
- Uniting Amide Synthesis and Activation by PJournal of the American Chemical Society · 2021Article
- Chemoselective γ-Oxidation of β,γ-Unsaturated Amides with TEMPO.Angewandte Chemie (International ed. in English) · 2021Article
- Chemoselektive γ-Oxidation von β,γ-ungesättigten Amiden mit TEMPO.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2021Article
- Chemoselective α-Sulfidation of Amides Using Sulfoxide Reagents.Organic letters · 2020Article
- An α-Cyclopropanation of Carbonyl Derivatives by Oxidative Umpolung.Angewandte Chemie (International ed. in English) · 2020Article
- Synthesis of Novel Heterocycles by Amide Activation and Umpolung Cyclization.Organic letters · 2020Article
- Unified Approach to the Chemoselective α-Functionalization of Amides with Heteroatom Nucleophiles.Journal of the American Chemical Society · 2019Article
- An umpolung strategy to react catalytic enols with nucleophiles.Nature communications · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A new approach for the synthesis of 1,4-dicarbonyl compounds is reported. Chemoselective activation of amide carbonyl functionality and subsequent umpolung via N-oxide addition generates an electrophilic enolonium species that can be coupled with a wide range of nucleophilic enolates. The method conveys broad functional group tolerance on both components, does not suffer from formation of homocoupling byproducts and avoids the use of transition metal catalysts.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.