Evidence map›Paper›PMID 29098933›Full record

ArticleThe Journal of international medical research2018

Association between monocyte chemoattractant protein-1 and blood pressure in smokers.

Maki Komiyama, Rieko Takanabe, Koh Ono, Sayaka Shimada, Hiromichi Wada, Hajime Yamakage, Noriko Satoh-Asahara, Tatsuya Morimoto, Akira Shimatsu, Yuko Takahashi and 1 more

Open access · goldAbstract read
In one paragraph

Article in The Journal of international medical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Cigarette Smoking and Atherosclerotic Cardiovascular Disease.Journal of atherosclerosis and thrombosis · 2024
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Current Status of Primary, Secondary, and Tertiary Prevention of Coronary Artery Disease.The International journal of angiology : official publication of the International College of Angiology, Inc · 2021
    Review
  9. Smoking and the Pathophysiology of Peripheral Artery Disease.Frontiers in cardiovascular medicine · 2021
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Maki Komiyama1 Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Rieko Takanabe1 Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Koh Ono2 Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Sayaka Shimada1 Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Hiromichi Wada1 Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Hajime Yamakage1 Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Noriko Satoh-Asahara1 Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Tatsuya Morimoto3 Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Akira Shimatsu1 Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Yuko Takahashi1 Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Koji Hasegawa1 Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Kyoto Medical Center · JPKyoto University · JPUniversity of Shizuoka · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective The expression level of monocyte chemoattractant protein-1 (MCP-1) is increased in atherosclerotic regions, inducing monocyte migration to the blood vessel wall. Although the serum MCP-1 concentration is higher in patients with than without cardiovascular disease, the precise correlations between the serum MCP-1 concentration and factors associated with smoking and atherosclerosis are unknown. Methods The serum MCP-1 concentration was measured using an enzyme-linked immunosorbent assay in 207 consecutive smokers who visited our smoking cessation clinic. Results Sex-adjusted analysis of smokers revealed that the MCP-1 concentration was positively correlated with age ( β = 0.311), smoking duration ( β = 0.342), systolic blood pressure ( β = 0.225), and diastolic blood pressure ( β = 0.137) but not with the body mass index. Multivariate regression analysis showed that smoking duration and systolic blood pressure were independent determinants of the MCP-1 concentration. Conclusions The MCP-1 concentration was positively correlated with blood pressure among smokers. Long-term smokers with high blood pressure may be more susceptible to plaque rupture at atherosclerotic lesion sites.

Indexed as

Blood PressureSmoking CessationAgedBiomarkersBlood Pressure DeterminationBody Mass IndexChemokine CCL2Cigarette SmokingFemaleHumansHypertensionMaleMiddle AgedMultivariate AnalysisProspective StudiesRetrospective StudiesBiomarkersCCL2 protein, humanChemokine CCL2atherosclerosisblood pressurecytokineinflammationMCP-1obesitySmoking

Identifiers

PMID29098933
PMCPMC5972233
OpenAlexW2766435153

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.