Evidence map›Paper›PMID 29098896›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2018

Synthesis and in vitro antiproliferative and antibacterial activity of new thiazolidine-2,4-dione derivatives.

Nazar Trotsko, Agata Przekora, Justyna Zalewska, Grażyna Ginalska, Agata Paneth, Monika Wujec

Abstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. TZD-Based Hybrid Molecules Act as Dual Anti-International journal of molecular sciences · 2023
    Article
  8. Article
  9. Review
  10. Design, synthesis andJournal of enzyme inhibition and medicinal chemistry · 2020
    Article
  11. Review
  12. Article
  13. Synthesis and In Vitro Anti-Molecules (Basel, Switzerland) · 2019
    Article
  14. Molecular Docking Evaluation of (Molecules (Basel, Switzerland) · 2018
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nazar Trotskoa Department of Organic Chemistry, Faculty of Pharmacy , Medical University of Lublin , Lublin , Poland.
Agata Przekorab Department of Biochemistry and Biotechnology, Faculty of Pharmacy , Medical University of Lublin , Lublin , Poland.
Justyna Zalewskab Department of Biochemistry and Biotechnology, Faculty of Pharmacy , Medical University of Lublin , Lublin , Poland.
Grażyna Ginalskab Department of Biochemistry and Biotechnology, Faculty of Pharmacy , Medical University of Lublin , Lublin , Poland.
Agata Panetha Department of Organic Chemistry, Faculty of Pharmacy , Medical University of Lublin , Lublin , Poland.
Monika Wujeca Department of Organic Chemistry, Faculty of Pharmacy , Medical University of Lublin , Lublin , Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In our present research, we synthesised new thiazolidine-2,4-diones (12-28). All the newly synthesised compounds were evaluated for antiproliferative and antibacterial activity. Antiproliferative evaluation was carried out using normal human skin fibroblasts and tumour cell lines: A549, HepG2, and MCF-7. The IC

Indexed as

Anti-Bacterial AgentsAntineoplastic AgentsCell LineCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorGram-Negative BacteriaGram-Positive BacteriaHumansMicrobial Sensitivity TestsMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipThiazolidinedionesAnti-Bacterial AgentsAntineoplastic Agentsthiazolidine-2,4-dioneThiazolidinedionesantibacterial activityAntiproliferative activityIC50thiazolidinedionesthiosemicarbazones

Identifiers

PMID29098896
PMCPMC6010082

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.