Evidence map›Paper›PMID 29098799›Full record

ArticlePediatric obesity2018

Prenatal traffic-related air pollution exposures, cord blood adipokines and infant weight.

T L Alderete, A Y Song, T Bastain, R Habre, C M Toledo-Corral, M T Salam, F Lurmann, F D Gilliland, C V Breton

Abstract read
In one paragraph

Article in Pediatric obesity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Timing determines programming of energy homeostasis by maternal PMEnvironmental pollution (Barking, Essex : 1987) · 2024
    Article
  6. Environmental PMeGastroenterology · 2024
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. PMEnvironmental research · 2022
    Article
  13. Article
  14. Near-roadway air pollution, immune cells and adipokines among obese young adults.Environmental health : a global access science source · 2022
    Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Early-life exposure to traffic-related air pollution and child anthropometry.Environmental epidemiology (Philadelphia, Pa.) · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

T L AldereteDepartment of Preventive Medicine, Division of Environmental Health, University of Southern California, Los Angeles, USA.
A Y SongDepartment of Preventive Medicine, Division of Environmental Health, University of Southern California, Los Angeles, USA.
T BastainDepartment of Preventive Medicine, Division of Environmental Health, University of Southern California, Los Angeles, USA.
R HabreDepartment of Preventive Medicine, Division of Environmental Health, University of Southern California, Los Angeles, USA.
C M Toledo-CorralDepartment of Public Health, California State University Los Angeles, Los Angeles, USA.
M T SalamKern Medical, University of Southern California, Los Angeles, USA.
F LurmannSonoma Technology, Inc., Petaluma, USA.
F D GillilandDepartment of Preventive Medicine, Division of Environmental Health, University of Southern California, Los Angeles, USA.
C V BretonDepartment of Preventive Medicine, Division of Environmental Health, University of Southern California, Los Angeles, USA.
University of Southern California · USCalifornia State University Los Angeles · USKern Medical Center · USSonoma Technology (United States) · US

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Joseph Leo Wiemels · 1996 to 2026
$46.4M
Lifecourse Approach to Developmental Repercussions of Environmental Agents on Metabolic and Respiratory health (LA DREAMERs)UG3OD023287 · OD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRETON, CARRIE VAN DOREN, GILLILAND, FRANK D. · 2016 to 2017
$6.5M
Training Grant in Genomic Analysis and InterpretationT32ES013678 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GAUDERMAN, WILLIAM JAMES, MCCONNELL, ROB S · 2006 to 2023
$5.6M
Southern California Children's Environmental Health Center (SC-CEHC)P01ES022845 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ALLAYEE, HOOMAN · 2013 to 2018
$4.0M
INTEGRATIVE GENETIC APPROACHES TO GENE-AIR POLLUTION INTERACTIONS IN ASTHMAR01ES021801 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AKBARI, OMID, ALLAYEE, HOOMAN · 2012 to 2016
$3.9M
Project 2: Environmental Exposures, Stress, and Maternal Pregnancy-Related Weight OutcomesP50ES026086 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HABRE, RIMA · 2015 to 2019
$3.7M
Mitochondrial epigenetics, traffic-related pollution and neonatal healthR21ES025870 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRETON, CARRIE VAN DOREN · 2015 to 2016
$468k
Near-Roadway and Ambient Air Pollution Exposure and the Gut Microbiome: Implications for Obesity and Insulin Resistance in AdolescenceK99ES027853 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ALDERETE, TANYA LYNN · 2017 to 2018
$202k
NIEHS NIH HHS K99 ES027853NIEHS NIH HHS P01 ES022845NIEHS NIH HHS P30 ES007048NIEHS NIH HHS P50 ES026086NIEHS NIH HHS R01 ES021801NIEHS NIH HHS R21 ES025870NIEHS NIH HHS T32 ES013678NIH HHS UG3 OD023287
6 · The paper itself

Abstract

objectiveStudies suggest that prenatal exposure to traffic-related air pollution (TRAP) may contribute to childhood obesity. While exact mechanisms for this association are unknown, circulating adipokines are hypothesized to contribute to early-life weight gain.

methodsThe Maternal and Child Health Study birth cohort included 136 women from the Los Angeles County + University of Southern California Medical Center. This study estimated prenatal residential TRAP exposure and used linear regression analysis to examine associations between adipokines with TRAP exposure and infant weight change (birth to 6 months).

resultsA one standard deviation (1-SD: 2 ppb) increase in prenatal non-freeway nitrogen oxides was associated with 33% (P = 0.01) higher leptin and 9% higher high molecular weight adiponectin levels (P = 0.07) in cord blood. Leptin levels were 71% higher in mothers who lived <75 m than those living >300 m from major roadways (P = 0.03). A 1-SD (10 ng mL

conclusionsHigher TRAP exposures were associated with higher cord blood levels of leptin and high molecular weight adiponectin. These adipokines were associated with increased infant weight change in female infants, which may have implications for future obesity risk.

Indexed as

AdipokinesAdultAir PollutantsAir PollutionBody WeightCaliforniaChildFemaleFetal BloodHumansInfantInfant, NewbornLinear ModelsMaleMothersPediatric ObesityAdipokinesAir PollutantsAir pollutioncord bloodhigh molecular weight adiponectinleptin

Identifiers

PMID29098799
PMCPMC5934325
OpenAlexW2766544020

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.