ArticleMolecular plant pathology2018
The cotton MAPK kinase GhMPK20 negatively regulates resistance to Fusarium oxysporum by mediating the MKK4-MPK20-WRKY40 cascade.
Article in Molecular plant pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 70 citations in OpenAlex.
- Pathogenicity and Virulence ofVirulence · 2026Review
- A new plant SUMO ligase, MPEL1, synergizes with MAPK16 to regulate resistance against Fusarium pathogens.The EMBO journal · 2026Article
- Review
- Characteristics of the MAPK gene family inJournal of genetics · 2025Article
- A fully phased, chromosome-scale genome of sugar beet line FC309 enables the discovery of Fusarium yellows resistance QTL.DNA research : an international journal for rapid publication of reports on genes and genomes · 2024Article
- Identification of MAPK Genes inInternational journal of molecular sciences · 2024Article
- GhMPK9-GhRAF39_1-GhWRKY40a Regulates the GhERF1b- and GhABF2-Mediated Pathways to Increase Cotton Disease Resistance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- GbPP2C80 Interacts with GbWAKL14 to Negatively Co-Regulate Resistance to Fusarium and Verticillium wilt via MPK3 and ROS Signaling in Sea Island Cotton.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Comprehensive analysis of MAPK gene family in upland cotton (Gossypium hirsutum) and functional characterization of GhMPK31 in regulating defense response to insect infestation.Plant cell reports · 2024Article
- Comprehensive transcriptome analyses of3 Biotech · 2023Article
- Metabolome and Transcriptome Profiling Reveals the Function of MdSYP121 in the Apple Response toInternational journal of molecular sciences · 2023Article
- Article
- Overexpression ofInternational journal of molecular sciences · 2023Article
- Article
- Defense Mechanisms of CottonInternational journal of molecular sciences · 2022Review
- Integrative Analysis of Expression Profiles of mRNA and MicroRNA Provides Insights of Cotton Response toInternational journal of molecular sciences · 2022Article
- MAP kinase cascades in plant development and immune signaling.EMBO reports · 2022Review
- Transcriptome Sequence Analysis of the Defense Responses of Resistant and Susceptible Cucumber Strains toFrontiers in plant science · 2022Article
- B-box containing protein 1 fromPeerJ · 2022Article
- GhWRKY21 regulates ABA-mediated drought tolerance by fine-tuning the expression of GhHAB in cotton.Plant cell reports · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Fusarium wilt is one of the most serious diseases affecting cotton. However, the pathogenesis and mechanism by which Fusarium oxysporum overcomes plant defence responses are unclear. Here, a new group D mitogen-activated protein kinase (MAPK) gene, GhMPK20, was identified and functionally analysed in cotton. GhMPK20 expression was significantly induced by F. oxysporum. Virus-induced gene silencing (VIGS) of GhMPK20 in cotton increased the tolerance to F. oxysporum, whereas ectopic GhMPK20 overexpression in Nicotiana benthamiana reduced F. oxysporum resistance via disruption of the salicylic acid (SA)-mediated defence pathway. More importantly, an F. oxysporum-induced MAPK cascade pathway composed of GhMKK4, GhMPK20 and GhWRKY40 was identified. VIGS of GhMKK4 and GhWRKY40 also enhanced F. oxysporum resistance in cotton, and the function of GhMKK4-GhMPK20 was shown to be essential for F. oxysporum-induced GhWRKY40 expression. Together, our results indicate that the GhMKK4-GhMPK20-GhWRKY40 cascade in cotton plays an important role in the pathogenesis of F. oxysporum. This research broadens our knowledge of the negative role of the MAPK cascade in disease resistance in cotton and provides an important scientific basis for the formulation of Fusarium wilt prevention strategies.
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