Evidence map›Paper›PMID 29098662›Full record

ArticleJournal of endocrinological investigation2018

Deregulation of the growth hormone/insulin-like growth factor-1 axis in adults with cystic fibrosis.

C Pascucci, R V De Biase, D Savi, S Quattrucci, A M Isidori, C Lubrano, L Gnessi, A Lenzi

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Article in Journal of endocrinological investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Endocrine Complications of Cystic Fibrosis.Clinics in chest medicine · 2022
    Review
  2. Article
  3. Article
  4. Review
  5. GH-IGF-1 Axis in Children with Cystic Fibrosis.Clinical medicine & research · 2019
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

C PascucciSection of Medical Pathophysiology, Endocrinology, Department Experimental Medicine, Sapienza University, 00161, Rome, Italy. chiarapascucci@libero.it.ORCID http://orcid.org/0000-0003-0827-5044
R V De BiasePediatrics Department, Cystic Fibrosis Regional Center, Sapienza University of Rome, Rome, Italy.
D SaviPediatrics Department, Cystic Fibrosis Regional Center, Sapienza University of Rome, Rome, Italy.
S QuattrucciPediatrics Department, Cystic Fibrosis Regional Center, Sapienza University of Rome, Rome, Italy.
A M IsidoriSection of Medical Pathophysiology, Endocrinology, Department Experimental Medicine, Sapienza University, 00161, Rome, Italy.
C LubranoSection of Medical Pathophysiology, Endocrinology, Department Experimental Medicine, Sapienza University, 00161, Rome, Italy.
L GnessiSection of Medical Pathophysiology, Endocrinology, Department Experimental Medicine, Sapienza University, 00161, Rome, Italy.
A LenziSection of Medical Pathophysiology, Endocrinology, Department Experimental Medicine, Sapienza University, 00161, Rome, Italy.
Sapienza University of Rome · ITBambino Gesù Children's Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePatients with cystic fibrosis (CF) present with signs and symptoms that overlap with those of adult growth hormone deficiency (GHD) syndrome: loss of muscle mass, bone fragility and lower stress tolerance. In literature, the prevalence of GHD in pediatric CF patients is higher than general population, but these studies have been performed on children with growth delay. To our knowledge, there are no studies on adult patients. The aim of this paper is to evaluate GH-IGF1 axis in an adult CF population.

methodsFifty clinically stable adult patients, 30 males; age 36 ± 2 years; BMI 21.39 ± 0.22 kg/m

resultsGHRH + Arginine test revealed the presence of GHD in 16 patients (32%); specifically 7 patients had a severe deficiency and 9 a partial deficiency.

conclusionsAdult patients with CF may show GHD. These patients should be followed over time to assess if the GHD could impact the clinical progression of CF.

Indexed as

AdolescentAdultArginineBiomarkersCystic FibrosisFemaleFollow-Up StudiesGrowth DisordersHuman Growth HormoneHumansInsulin-Like Growth Factor IMaleMiddle AgedPrognosisYoung AdultArginineBiomarkersHuman Growth HormoneIGF1 protein, humanInsulin-Like Growth Factor IAdult patientsCystic fibrosisGrowth hormone deficiencyInsulin-like growth factor-1

Identifiers

PMID29098662
OpenAlexW2766933782

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.