Evidence map›Paper›PMID 29098529›Full record

ArticleJournal of natural medicines2018

18β-glycyrrhetinic acid inhibits migration and invasion of human gastric cancer cells via the ROS/PKC-α/ERK pathway.

Hongke Cai, Xi Chen, Jianbo Zhang, Jijian Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of natural medicines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Hongke CaiDepartment of Gastrointestinal Surgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Xi ChenCenter of Molecular Medicine and Cancer Research, Chongqing Medical University, Chongqing, China.
Jianbo ZhangDepartment of Gastrointestinal Surgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China. 149956847@qq.com.
Jijian WangDepartment of Gastrointestinal Surgery, Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China. 18223138243@163.com.
Second Affiliated Hospital of Chongqing Medical University · CNChongqing Medical University · CNDalian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

18β-glycyrrhetinic acid (18β-GA) is a bioactive component of licorice root which exerts pharmacological activities including anti-inflammatory, antiviral, anti-oxidative and anti-cancer effects. The current study further investigated the molecular mechanisms associated with the inhibitory effects of 18β-GA on tumor metastasis in human gastric cancer cells. The results indicated that 18β-GA significantly reduced invasion and migration activities and suppressed MMP-2 and 9 activities on SGC-7901cells in a dose-dependent manner. Further study showed 18β-GA upregulated E-cadherin expression but downregulated vimentin expression. The results also showed that 18β-GA inhibited ROS formation, PKC-α expression and the phosphorylation of ERK in a dose-dependent manner. In conclusion, this study revealed that 18β-GA inhibits migration and invasion via the ROS/PKC-α/ERK signaling pathway in gastric cancer cells. This suggests that 18β-GA has the potential to be used as an effective chemopreventive agent for the prevention of gastric cancer metastasis.

Indexed as

Cell MovementGlycyrrhetinic AcidHumansMAP Kinase Signaling SystemNeoplasm InvasivenessReactive Oxygen SpeciesStomach Neoplasms18alpha-glycyrrhetinic acidGlycyrrhetinic AcidReactive Oxygen Species18β-glycyrrhetinic acidGastric cancerInvasionMigrationROS

Identifiers

PMID29098529
OpenAlexW2767167306

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.