ArticleBreast cancer research and treatment2018
Safety of fertility preservation in breast cancer patients in a register-based matched cohort study.
Article in Breast cancer research and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Safety of fertility preservation techniques before and after anticancer treatments in young women with breast cancer: a systematic review and meta-analysis.Human reproduction (Oxford, England) · 2022Pooled it
- Oocyte and embryo cryopreservation before gonadotoxic treatments: Principles of safe ovarian stimulation, a systematic review.Women's health (London, England)Pooled it
- Global disparities in fertility preservation among young breast cancer patients: a systematic review and meta-analysis of utilization rates and associated factors.International journal of nursing studies advances · 2026Review
- Oncologic Safety of Preoperative Controlled Ovarian Stimulation for Fertility Preservation Among Women with Estrogen Receptor Positive Breast Cancer.Annals of surgical oncology · 2026Article
- Breast Cancer and Ovarian Tissue Cryopreservation: SWOT Analysis.Journal of clinical medicine · 2026Article
- Reproductive outcomes after fertility preservation using tamoxifen or letrozole in women with breast cancer: a long-term follow-up.F&S reports · 2026Article
- Coping with breast cancer in Ghana: a qualitative study of women's lived experiences following breast cancer diagnosis.BMC cancer · 2026Article
- Prevalence and impact of fertility concerns in young women with breast cancer.Scientific reports · 2024Article
- Is controlled ovarian stimulation safe in patients with hormone receptor-positive breast cancer receiving neoadjuvant chemotherapy?ESMO open · 2024Review
- The Late Effects of Cancer Treatment on Female Fertility and the Current Status of Fertility Preservation-A Narrative Review.Life (Basel, Switzerland) · 2023Review
- Fertility-sparing options for cancer patients.Abdominal radiology (New York) · 2023Review
- Risk of thrombosis in women with cancer undergoing controlled ovarian hyperstimulation for fertility preservation.Journal of assisted reproduction and genetics · 2022Article
- Risk of recurrence and pregnancy outcomes in young women with breast cancer who do and do not undergo fertility preservation.Breast cancer research and treatment · 2022Article
- Fertility preservation in patients of childbearing age treated for breast cancer: A nationwide cohort study.Breast (Edinburgh, Scotland) · 2022Article
- Surgeon and Patient Reports of Fertility Preservation Referral and Uptake in a Prospective, Pan-Canadian Study of Young Women with Breast Cancer.Annals of surgical oncology · 2022Article
- Hereditary breast cancer and fertility preservation outcomes.Journal of assisted reproduction and genetics · 2022Article
- Installing oncofertility programs for breast cancer in limited versus optimum resource settings: Empirical data from 39 surveyed centers in Repro-Can-OPEN Study Part I & II.Journal of assisted reproduction and genetics · 2022Article
- Hot Topics on Fertility Preservation for Women and Girls-Current Research, Knowledge Gaps, and Future Possibilities.Journal of clinical medicine · 2021Review
- Predictors and outcomes in breast cancer patients who did or did not pursue fertility preservation.Breast cancer research and treatment · 2021Article
- Gonadotrophin stimulation and risk of relapse in breast cancer.Human reproduction open · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo determine if women with breast cancer that undergo fertility preservation (FP), with or without hormonal stimulation, present with an increased risk of breast cancer recurrence.
methodsA matched cohort study on women with breast cancer attempting to ensure FP in Stockholm from 1999 to 2013 [exposed women (n = 188), age-matched unexposed controls (n = 378)] was designed using the Stockholm regional data from the Swedish National Breast Cancer Quality Register. Breast cancer relapse rates [incidence rate ratio (IRR)] and 95% confidence interval (CI) were estimated using Cox regression and adjusted for potential confounding factors. Completeness of the registry at the time of the study was close to 99%.
resultsMost women attempted FP by hormonal stimulation treatment (n = 148, 79%) with the objective of freezing their eggs or embryos. A smaller group elected FP methods without hormone stimulation (n = 40, 21%). Women who received hormone stimulation did not present with a higher relapse rate than unexposed control women in a model adjusted for age and calendar period of diagnosis (IRR 0.59, 95% CI 0.34-1.04). The results remained virtually unchanged after adjustment for tumor size, estrogen receptor status, affected lymph nodes, and chemotherapy treatment (IRR 0.66, 95% CI 0.37-1.17).
conclusionEvidence was not found that fertility preservation, with or without hormonal stimulation, was associated with an increased risk of breast cancer recurrence. The high coverage rate of this population-based study supports the safe practice of fertility preservation in young women with breast cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.