Evidence map›Paper›PMID 29098466›Full record

ArticleEuropean child & adolescent psychiatry2018

Prevalence and predictors of hair pulling disorder and excoriation disorder in Tourette syndrome.

Erica Greenberg, Esther S Tung, Caitlin Gauvin, Lisa Osiecki, Kelly G Yang, Erin Curley, Angela Essa, Cornelia Illmann, Paul Sandor, Yves Dion and 11 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European child & adolescent psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 3 pooled it
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Psychiatric Diagnoses and Medications in Wolfram Syndrome.Scandinavian journal of child and adolescent psychiatry and psychology · 2022
    Article
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 10 institutions in 2 countries.

Erica GreenbergDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Esther S TungDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Caitlin GauvinPsychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry, Center for Genomic Medicine, Massachusetts General Hospital, 185 Cambridge Street, CPZN-6254, Boston, MA, 02114, USA.
Lisa OsieckiPsychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry, Center for Genomic Medicine, Massachusetts General Hospital, 185 Cambridge Street, CPZN-6254, Boston, MA, 02114, USA.
Kelly G YangPsychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry, Center for Genomic Medicine, Massachusetts General Hospital, 185 Cambridge Street, CPZN-6254, Boston, MA, 02114, USA.
Erin CurleyDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Angela EssaPsychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry, Center for Genomic Medicine, Massachusetts General Hospital, 185 Cambridge Street, CPZN-6254, Boston, MA, 02114, USA.
Cornelia IllmannPsychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry, Center for Genomic Medicine, Massachusetts General Hospital, 185 Cambridge Street, CPZN-6254, Boston, MA, 02114, USA.
Paul SandorDepartment of Psychiatry, Youthdale Treatment Centers, University of Toronto and University Health Network, Toronto, ON, Canada.
Yves DionDepartment of Psychiatry, University of Montreal, Montreal, QC, Canada.
Gholson J LyonCold Spring Harbor Laboratory, Stanley Institute for Cognitive Genomics, Cold Spring Harbor, NY, USA.
Robert A KingYale Child Study Center, Yale University School of Medicine, New Haven, CT, USA.
Sabrina DarrowDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.
Matthew E HirschtrittDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA, USA.
Cathy L BudmanHofstra Northwell School of Medicine, Hempstead, NY, USA.
Marco GradosDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
David L PaulsPsychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry, Center for Genomic Medicine, Massachusetts General Hospital, 185 Cambridge Street, CPZN-6254, Boston, MA, 02114, USA.
Nancy J KeuthenDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Carol A MathewsDepartment of Psychiatry, Genetics Institute, University of Florida, Gainesville, FL, USA.
Jeremiah M ScharfPsychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry, Center for Genomic Medicine, Massachusetts General Hospital, 185 Cambridge Street, CPZN-6254, Boston, MA, 02114, USA. jscharf@partners.org.ORCID http://orcid.org/0000-0002-4742-5896
Tourette Association of America International Consortium for Genetics
Massachusetts General Hospital · USUniversity of California, San Francisco · USBrigham and Women's Hospital · USCold Spring Harbor Laboratory · USHofstra University · USJohns Hopkins University · USUniversité de Montréal · CAUniversity Health Network · CAUniversity of Florida · USYale University · US

Funding

A Genetic Linkage Study of GTSU01NS040024 · NINDS · TOURETTE ASSOCIATION OF AMERICA, INC. · PI SCHARF, JEREMIAH M · 2007 to 2012
$8.0M
Refining the Tourette Syndrome phenotype across diagnoses to aid gene discoveryR01MH096767 · NIMH · UNIVERSITY OF FLORIDA · PI MATHEWS, CAROL A · 2013 to 2015
$1.2M
Advancing Tourette Syndrome genetics using bioinformatics and genome biologyK02NS085048 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SCHARF, JEREMIAH M · 2014 to 2018
$1.0M
Translational phenomics and genomics of Gilles de la Tourette SyndromeK23MH085057 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI SCHARF, JEREMIAH M · 2009 to 2013
$929k
National Institute of Mental Health K23MH085057National Institute of Mental Health R01MH096767National Institute of Neurological Disorders and Stroke U01NS40024NIMH NIH HHS K23 MH085057NIMH NIH HHS R01 MH096767NINDS NIH HHS K02 NS085048NINDS NIH HHS U01 NS040024
6 · The paper itself

Abstract

Trichotillomania/hair pulling disorder (HPD) and excoriation/skin picking disorder (SPD) are childhood-onset, body-focused repetitive behaviors that are thought to share genetic susceptibility and underlying pathophysiology with obsessive-compulsive disorder (OCD) and Tourette syndrome (TS). We sought to determine the prevalence of DSM-5 HPD and SPD in TS patients, and to identify clinical factors most associated with their co-morbidity with TS. Participants included 811 TS patients recruited from TS specialty clinics for a multi-center genetic study. Patients were assessed using standardized, validated semi-structured interviews. HPD and SPD diagnoses were determined using a validated self-report questionnaire. HPD/SPD prevalence rates were calculated, and clinical predictors were evaluated using regression modeling. 3.8 and 13.0% of TS patients met DSM-5 criteria for HPD and SPD, respectively. In univariable analyses, female sex, OCD, and both tic and obsessive-compulsive symptom severity were among those associated with HPD and/or SPD. In multivariable analyses, only lifetime worst-ever motor tic severity remained significantly associated with HPD. Female sex, co-occurring OCD, ADHD, and motor tic severity remained independently associated with SPD. This is the first study to examine HPD and SPD prevalence in a TS sample using semi-structured diagnostic instruments. The prevalence of HPD and SPD in TS patients, and their association with increased tic severity and co-occurring OCD, suggests that clinicians should screen children with TS and related disorders for HPD/SPD, particularly in females and in those with co-occurring OCD. This study also helps set a foundation for subsequent research regarding HPD/SPD risk factors, pathophysiology, and treatment models.

Indexed as

ChildComorbidityFemaleHumansMaleObsessive-Compulsive DisorderPrevalenceSelf-Injurious BehaviorSurveys and QuestionnairesTourette SyndromeTrichotillomaniaBody-focused repetitive behaviorsExcoriation disorder/skin picking disorderObsessive–compulsive disorderTourette syndromeTrichotillomania/hair pulling disorder

Identifiers

PMID29098466
PMCPMC5932289
OpenAlexW2765820710

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.