ArticleJournal of neural transmission (Vienna, Austria : 1996)2017
Tremor in multiple sclerosis is associated with cerebello-thalamic pathology.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Pathophysiology of Cerebellar Tremor: The Forward Model-Related Tremor and the Inferior Olive Oscillation-Related Tremor.Frontiers in neurology · 2021Pooled it
- Microstructural alterations of cerebellar peduncles in multiple sclerosis: a diffusion tensor imaging study.Acta neurologica Belgica · 2025Article
- Altered Functional Activation Is Associated With Speech Dysfunction in People With Multiple Sclerosis.Neurobiology of language (Cambridge, Mass.) · 2025Article
- Volumetric and diffusion MRI abnormalities associated with dysarthria in multiple sclerosis.Brain communications · 2024Article
- Tremor in Patients with Relapsing-Remitting Multiple Sclerosis: Clinical Characteristics and Impact on Quality of Life.Movement disorders clinical practice · 2023Article
- Movement Disorders in Multiple Sclerosis: An Update.Tremor and other hyperkinetic movements (New York, N.Y.) · 2022Review
- Task-based functional MRI challenges in clinical neuroscience: Choice of the best head motion correction approach in multiple sclerosis.Frontiers in neuroscience · 2022Article
- Simultaneous lesion and brain segmentation in multiple sclerosis using deep neural networks.Scientific reports · 2021Article
- Tremor in Multiple Sclerosis-An Overview and Future Perspectives.Brain sciences · 2020Article
- Mechanisms and Pharmacotherapy for Ethanol-Responsive Movement Disorders.Frontiers in neurology · 2020Review
- The Cerebellar Thalamus.Cerebellum (London, England) · 2019Review
- Novel Functional MRI Task for Studying the Neural Correlates of Upper Limb Tremor.Frontiers in neurology · 2018Article
- Identifying the white matter pathways involved in multiple sclerosis-related tremor using diffusion tensor imaging.Multiple sclerosis journal - experimental, translational and clinicalArticle
- Movement Disorder in Demyelinating Disease: Tracing the Charcot's Foot Print.Annals of Indian Academy of NeurologyArticle
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tremor in people with multiple sclerosis (MS) is a frequent and debilitating symptom with a relatively poorly understood pathophysiology. To determine the relationship between clinical tremor severity and structural magnetic resonance imaging parameters. Eleven patients with clinically definite MS and right-sided upper limb tremor were studied. Tremor severity was assessed using the Bain score (overall severity, writing, and Archimedes spiral drawing). Cerebellar dysfunction was assessed using the Scale for the Assessment and Rating of Ataxia. Dystonia was assessed using the Global Dystonia Scale adapted for upper limb. For all subjects, volume was calculated for the thalamus from T1-weighted volumetric scans using Freesurfer. Superior cerebellar peduncle (SCP) cross-sectional areas were measured manually. The presence of lesions was visually determined and the lesion volumes were calculated by the lesion growth algorithm as implemented in the Lesion Segmentation Toolbox. Right thalamic volume negatively correlated with Bain tremor severity score (ρ = - 0.65, p = 0.03). Left thalamic volume negatively correlated with general Bain tremor severity score (ρ = - 0.65, p = 0.03) and the Bain writing score (ρ = - 0.65, p = 0.03). Right SCP area negatively correlated with Bain writing score (ρ = - 0.69, p = 0.02). Finally, Bain Archimedes score was significantly higher in patients with lesions in the contralateral thalamus. Whole brain lesion load showed no relationship with tremor severity. These results implicate degeneration of key structures within the cerebello-thalamic pathway as pathological substrates for tremor in MS patients.
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