Evidence map›Paper›PMID 29098407›Full record

ArticleHeart and vessels2018

Cytoprotective effects of transgenic neuroglobin overexpression in an acute and chronic mouse model of ischemic heart disease.

Evi Luyckx, Bert R Everaert, Bieke Van der Veken, Wendy Van Leuven, Jean-Pierre Timmermans, Christiaan J Vrints, Guido R Y De Meyer, Wim Martinet, Sylvia Dewilde

Abstract read
PubMed Publisher
In one paragraph

Article in Heart and vessels, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Neuroglobin Expression Models as a Tool to Study Its Function.Oxidative medicine and cellular longevity · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Evi LuyckxProtein Chemistry, Proteomics and Epigenetic Signalling, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.
Bert R EveraertLaboratory of Cell Biology and Histology, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.
Bieke Van der VekenLaboratory of Physiopharmacology, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.
Wendy Van LeuvenProtein Chemistry, Proteomics and Epigenetic Signalling, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.
Jean-Pierre TimmermansLaboratory of Cell Biology and Histology, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.
Christiaan J VrintsLaboratory of Cellular and Molecular Cardiology, Antwerp University Hospital, Wilrijkstraat 10, 2650, Edegem, Belgium.
Guido R Y De MeyerLaboratory of Physiopharmacology, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.
Wim MartinetLaboratory of Physiopharmacology, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.
Sylvia DewildeProtein Chemistry, Proteomics and Epigenetic Signalling, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium. sylvia.dewilde@uantwerpen.be.
University of Antwerp · BEAntwerp University Hospital · BE

Funding

Universiteit Antwerpen DOCPRO-BOF
6 · The paper itself

Abstract

Neuroglobin (NGB) is an oxygen-binding protein that is mainly expressed in nervous tissues where it is considered to be neuroprotective during ischemic brain injury. Interestingly, transgenic mice overexpressing NGB reveal cytoprotective effects on tissues lacking endogenous NGB, which might indicate a therapeutic role for NGB in a broad range of ischemic conditions. In the present study, we investigated the effect of NGB overexpression on survival as well as on the size and occurrence of myocardial infarctions (MI) in a mouse model of acute MI (AMI) and a model of advanced atherosclerosis (ApoE

Indexed as

Gene Expression RegulationAcute DiseaseAnimalsChronic DiseaseCytoprotectionDisease Models, AnimalGlobinsMaleMiceMice, Inbred C57BLMice, TransgenicMyocardial IschemiaMyocardiumNerve Tissue ProteinsNeuroglobinOxidative StressGlobinsNerve Tissue ProteinsNeuroglobinRNAAtherosclerosisCytoprotectionIschemiaMyocardial infarctionNeuroglobin

Identifiers

PMID29098407
OpenAlexW2765207308

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.