Evidence map›Paper›PMID 29098164›Full record

ArticleBioMed research international2017

Cell Signaling Pathway in 12-O-Tetradecanoylphorbol-13-acetate-Induced LCN2 Gene Transcription in Esophageal Squamous Cell Carcinoma.

Lingying Meng, Muting Wang, Zepeng Du, Zhongmin Fang, Bingli Wu, Jianyi Wu, Wenming Xie, Jian Shen, Tianxiang Zhu, XieE Xu and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Pharmacogenomics and personalized medicine · 2021
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Lingying MengDepartment of Cardiothoracic Surgery, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou, Guangdong 515041, China.
Muting WangDepartment of Cardiothoracic Surgery, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou, Guangdong 515041, China.
Zepeng DuDepartment of Pathology, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou, Guangdong 515041, China.
Zhongmin FangDepartment of Cardiothoracic Surgery, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou, Guangdong 515041, China.
Bingli WuDepartment of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou, Guangdong 515041, China.ORCID 0000-0002-0614-4721
Jianyi WuDepartment of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou, Guangdong 515041, China.
Wenming XieNetwork and Information Center, Shantou University Medical College, Shantou 515041, China.
Jian ShenDepartment of Oncologic Pathology, Shantou University Medical College, Shantou, Guangdong 515041, China.
Tianxiang ZhuDepartment of Cardiothoracic Surgery, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou, Guangdong 515041, China.
XieE XuDepartment of Oncologic Pathology, Shantou University Medical College, Shantou, Guangdong 515041, China.
Liandi LiaoDepartment of Oncologic Pathology, Shantou University Medical College, Shantou, Guangdong 515041, China.
Liyan XuDepartment of Oncologic Pathology, Shantou University Medical College, Shantou, Guangdong 515041, China.
Enmin LiDepartment of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou, Guangdong 515041, China.ORCID 0000-0001-6375-3614
Bin LanDepartment of Cardiothoracic Surgery, Shantou Central Hospital, Affiliated Shantou Hospital of Sun Yat-sen University, Shantou, Guangdong 515041, China.ORCID 0000-0003-3121-7643
Shantou University · CNShantou Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

LCN2 is involved in various cellular functions, including transport of small hydrophobic molecules, protection of MMP9 from proteolytic degradation, and regulating innate immunity. LCN2 is elevated in multiple human cancers, frequently being associated with tumor size, stage, and invasiveness. Our previous studies have shown that LCN2 expression could be induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in esophageal squamous cell carcinoma (ESCC) by the binding of five nucleoproteins (MISP, KLF10, KLF15, PPP1R18, and RXR

Indexed as

Transcription, GeneticCarcinoma, Squamous CellCell Line, TumorEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaGene Expression Regulation, NeoplasticHumansLipocalin-2MAP Kinase Signaling SystemMatrix Metalloproteinase 9Neoplasm InvasivenessNeoplasm ProteinsPromoter Regions, GeneticProtein Kinase C-alphaSignal TransductionTetradecanoylphorbol AcetateLCN2 protein, humanLipocalin-2Matrix Metalloproteinase 9MMP9 protein, humanNeoplasm ProteinsPRKCA protein, humanProtein Kinase C-alphaTetradecanoylphorbol Acetate

Identifiers

PMID29098164
PMCPMC5642883
OpenAlexW2760911511

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.