Evidence map›Paper›PMID 29097998›Full record

ArticleFrontiers in immunology2017

Differential Relationships among Circulating Inflammatory and Immune Activation Biomediators and Impact of Aging and Human Immunodeficiency Virus Infection in a Cohort of Injection Drug Users.

Gregory D Kirk, Stewart Dandorf, Huifen Li, Yiyin Chen, Shruti H Mehta, Damani A Piggott, Joseph B Margolick, Sean X Leng

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Gregory D KirkDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Stewart DandorfDivision of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Huifen LiDivision of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Yiyin ChenDivision of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Shruti H MehtaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Damani A PiggottDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Joseph B MargolickDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Sean X LengDivision of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Johns Hopkins University · USJohns Hopkins Medicine · US

Funding

The AIDS Linked to the Intravenous Experience (ALIVE) StudyU01DA036297 · NIDA · JOHNS HOPKINS UNIVERSITY · PI Gregory D Kirk, Shruti H Mehta · 2014 to 2026
$28.9M
INCIDENCE OF HIV INFECTIONS IN A COHORT OF IV DRUG USERSR01DA012568 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MEHTA, SHRUTI H · 1999 to 2017
$15.5M
THE NATURAL HISTORY OF HIV INFECTION AMONG DRUG USERSR01DA004334 · NIDA · JOHNS HOPKINS UNIVERSITY · PI KIRK, GREGORY D · 1987 to 2011
$7.6M
Influenza vaccine failure in adults over age 75: role of chronic CMV infectionR01AI108907 · NIAID · JOHNS HOPKINS UNIVERSITY · PI LENG, SEAN XIAO · 2014 to 2018
$2.8M
Real Time Methods for Quantifying Exposure to Illicit Drugs & Psychosocial StressU01DA023832 · NIDA · JOHNS HOPKINS UNIVERSITY · PI KIRK, GREGORY D · 2007 to 2010
$1.9M
Epidemiology and Mechanisms of Accelerated Aging in HIV InfectionRC1AI086053 · NIAID · JOHNS HOPKINS UNIVERSITY · PI KIRK, GREGORY D · 2009 to 2010
$995k
INCIDENCE OF HIV INFECTION IN A COHORT OF IV DRUG USERSR56DA012568 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MEHTA, SHRUTI H · 2013 to 2013
$833k
Chronic CMV infection in the elderly: diagnosis and link to chronic inflammationR21AG043874 · NIA · JOHNS HOPKINS UNIVERSITY · PI LENG, SEAN XIAO · 2013 to 2014
$446k
NIAID NIH HHS R01 AI108907NIAID NIH HHS RC1 AI086053NIA NIH HHS R21 AG043874NIDA NIH HHS R01 DA004334NIDA NIH HHS R01 DA012568NIDA NIH HHS R56 DA012568NIDA NIH HHS U01 DA023832NIDA NIH HHS U01 DA036297
6 · The paper itself

Abstract

As individuals with human immunodeficiency virus (HIV) infection live longer, aging and age-related chronic conditions have become major health concerns for this vulnerable population. Substantial evidence suggests that chronic inflammation and immune activation contribute significantly to chronic conditions in people aging with or without HIV infection. As a result, increasing numbers of inflammation and immune activation biomediators have been measured. While very few studies describe their

Indexed as

CRPhuman immunodeficiency virus infection and agingIL-6neopterinsTNFR-1sTNFR-2

Identifiers

PMID29097998
PMCPMC5653695
OpenAlexW2766448221

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.