Evidence map›Paper›PMID 29097944›Full record

ArticleContrast media & molecular imaging2017

Multimodal Imaging Nanoparticles Derived from Hyaluronic Acid for Integrated Preoperative and Intraoperative Cancer Imaging.

William M Payne, Tanner K Hill, Denis Svechkarev, Megan B Holmes, Balasrinivasa R Sajja, Aaron M Mohs

Abstract read
In one paragraph

Article in Contrast media & molecular imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Image-guided tumor surgery: The emerging role of nanotechnology.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2020
    Review
  6. Review
  7. Medical imaging modalities using nanoprobes for cancer diagnosis: A literature review on recent findings.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2019
    Review
  8. Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

William M PayneDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0001-7872-4963
Tanner K HillDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA.
Denis SvechkarevDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA.
Megan B HolmesDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA.
Balasrinivasa R SajjaDepartment of Radiology, University of Nebraska Medical Center, Omaha, NE, USA.
Aaron M MohsDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA.ORCID 0000-0002-9353-5404

Funding

UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Joann B. Sweasy · 1985 to 2026
$55.0M
Project 9 - Renal Drug Targeting for the Treatment of Lupus NephritisP20GM103480 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BRONICH, TATIANA K · 2012 to 2017
$13.3M
Hyaluronic Acid Based Nanoparticles for Targeted Image-Guided Tumor SurgeryR01EB019449 · NIBIB · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MOHS, AARON M. · 2014 to 2017
$1.3M
NCI NIH HHS P30 CA036727NIBIB NIH HHS R01 EB019449NIGMS NIH HHS P20 GM103480
6 · The paper itself

Abstract

Surgical resection remains the most promising treatment strategy for many types of cancer. Residual malignant tissue after surgery, a consequence in part due to positive margins, contributes to high mortality and disease recurrence. In this study, multimodal contrast agents for integrated preoperative magnetic resonance imaging (MRI) and intraoperative fluorescence image-guided surgery (FIGS) are developed. Self-assembled multimodal imaging nanoparticles (SAMINs) were developed as a mixed micelle formulation using amphiphilic HA polymers functionalized with either GdDTPA for

Indexed as

Hyaluronic AcidAnimalsBreast NeoplasmsFemaleHeterograftsHumansIntraoperative PeriodMagnetic Resonance ImagingMiceMultimodal ImagingNanoparticlesOptical ImagingPhantoms, ImagingPreoperative PeriodSurgery, Computer-AssistedHyaluronic Acid

Identifiers

PMID29097944
PMCPMC5612698

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.