Evidence map›Paper›PMID 29097911›Full record

ArticleContrast media & molecular imaging2017

MicroPET/CT Imaging of AXL Downregulation by HSP90 Inhibition in Triple-Negative Breast Cancer.

Wanqin Wang, Jun Zhao, Xiaoxia Wen, Curtis Chun-Jen Lin, Junjie Li, Qian Huang, Yongqiang Yu, Shiaw-Yih Lin, Chun Li

Open access · hybridAbstract read
In one paragraph

Article in Contrast media & molecular imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Wanqin WangDepartment of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0003-4856-6348
Jun ZhaoDepartment of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Xiaoxia WenDepartment of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Curtis Chun-Jen LinDepartment of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Junjie LiDepartment of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Qian HuangDepartment of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Yongqiang YuDepartment of Radiology, The 1st Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.ORCID 0000-0001-8977-2215
Shiaw-Yih LinDepartment of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-3838-0358
Chun LiDepartment of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-2376-4703
The University of Texas MD Anderson Cancer Center · USAnhui Medical University · CN

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

AXL receptor tyrosine kinase is overexpressed in a number of solid tumor types including triple-negative breast cancer (TNBC). AXL is considered an important regulator of epithelial-to-mesenchymal transition (EMT) and a potential therapeutic target for TNBC. In this work, we used microPET/CT with

Indexed as

AnimalsAntibodiesAxl Receptor Tyrosine KinaseBenzoquinonesCell Line, TumorCell ProliferationCopper RadioisotopesDown-RegulationEpithelial-Mesenchymal TransitionFemaleHSP90 Heat-Shock ProteinsHumansLactams, MacrocyclicMicePositron Emission Tomography Computed TomographyProto-Oncogene ProteinsAntibodiesAxl Receptor Tyrosine KinaseBenzoquinonesCopper-64Copper RadioisotopesHSP90 Heat-Shock ProteinsLactams, MacrocyclicProto-Oncogene ProteinsReceptor Protein-Tyrosine Kinasestanespimycin

Identifiers

PMID29097911
PMCPMC5612679
OpenAlexW2613120566

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.