Evidence map›Paper›PMID 29097815›Full record

ArticleScientific reports2017

Puerarin attenuates diabetic kidney injury through the suppression of NOX4 expression in podocytes.

Xueling Li, Weijing Cai, Kyung Lee, Bohan Liu, Yueyi Deng, Yiping Chen, Xianwen Zhang, John Cijiang He, Yifei Zhong

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Combination of canagliflozin and puerarin alleviates the lipotoxicity to diabetic kidney in mice.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2023
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Sirtuin Family and Diabetic Kidney Disease.Frontiers in endocrinology · 2022
    Review
  15. Article
  16. Sirtuins and Renal Oxidative Stress.Antioxidants (Basel, Switzerland) · 2021
    Review
  17. Molecular Mechanism ofFrontiers in pharmacology · 2021
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Xueling LiDivision of Nephrology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Weijing CaiDepartment of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, NY, USA.
Kyung LeeDepartment of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, NY, USA.
Bohan LiuDepartment of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, NY, USA.
Yueyi DengDivision of Nephrology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yiping ChenDivision of Nephrology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xianwen ZhangDivision of Nephrology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
John Cijiang HeDepartment of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, NY, USA. cijiang.he@mssm.edu.
Yifei ZhongDivision of Nephrology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. yifeilily@126.com.
Icahn School of Medicine at Mount Sinai · USShanghai University of Traditional Chinese Medicine · CNLonghua Hospital Shanghai University of Traditional Chinese Medicine · CN

Funding

Role of HIPK2 in Kidney Tubulointerstitial InjuryR01DK088541 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HE, JOHN CIJIANG · 2010 to 2019
$4.0M
Cellular and molecular mechanisms of retinoids in podocytesR01DK078897 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HE, JOHN CIJIANG · 2007 to 2018
$3.6M
NIDDK NIH HHS R01 DK078897NIDDK NIH HHS R01 DK088541
6 · The paper itself

Abstract

Radix puerariae, a traditional Chinese herbal medication, has been used to treat patients with diabetic nephropathy (DN). Several studies demonstrated that puerarin, the active compound of radix puerariae, reduces diabetic injury in streptozotocin (STZ)-induced diabetic rodent models. However, as STZ injection alone results in mild kidney injury, the therapeutic benefit afforded by puerarin in DN remained inconclusive. Thus we sought to clarify the role of puerarin by employing an accelerated DN model, STZ-induced diabetes in the endothelial nitric oxide synthase-null (eNOS

Indexed as

AlbuminuriaAnimalsCells, CulturedDiabetes Mellitus, ExperimentalDiabetic NephropathiesGlucoseHypoglycemic AgentsIsoflavonesMaleMice, Inbred C57BLMice, KnockoutNADPH Oxidase 4NF-kappa BNitric Oxide Synthase Type IIIOxidative StressPodocytesGlucoseHypoglycemic AgentsIsoflavonesNADPH Oxidase 4NF-kappa BNitric Oxide Synthase Type IIINos3 protein, mouseNox4 protein, mouseProtective AgentspuerarinRNA, MessengerSirt1 protein, mouseSirtuin 1Superoxides

Identifiers

PMID29097815
PMCPMC5668268
OpenAlexW2765836406

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.