Evidence map›Paper›PMID 29097799›Full record

ArticleScientific reports2017

Dual targeting improves capture of ultrasound microbubbles towards activated platelets but yields no additional benefit for imaging of arterial thrombosis.

F Günther, T Heidt, M Kramer, E Khanicheh, A L Klibanov, A Geibel-Zehender, E A Ferrante, I Hilgendorf, D Wolf, A Zirlik and 5 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 4 countries.

F GüntherHeart Center Freiburg University and Faculty of Medicine, University of Freiburg, Freiburg, Germany.
T HeidtHeart Center Freiburg University and Faculty of Medicine, University of Freiburg, Freiburg, Germany.
M KramerHeart Center Freiburg University and Faculty of Medicine, University of Freiburg, Freiburg, Germany.
E KhanichehUniversity Hospital of Basel, Basel, Switzerland.
A L KlibanovUniversity of Virginia, Charlottesville, USA.
A Geibel-ZehenderHeart Center Freiburg University and Faculty of Medicine, University of Freiburg, Freiburg, Germany.
E A FerranteNational Institute of Health, NHLBI, Bethesda, USA.
I HilgendorfHeart Center Freiburg University and Faculty of Medicine, University of Freiburg, Freiburg, Germany.
D WolfHeart Center Freiburg University and Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0003-1525-4348
A ZirlikHeart Center Freiburg University and Faculty of Medicine, University of Freiburg, Freiburg, Germany.
J ReinöhlHeart Center Freiburg University and Faculty of Medicine, University of Freiburg, Freiburg, Germany.
C BodeHeart Center Freiburg University and Faculty of Medicine, University of Freiburg, Freiburg, Germany.
K PeterBaker IDI Heart and Diabetes Institute, Melbourne, Australia.
B A KaufmannUniversity Hospital of Basel, Basel, Switzerland.
C von Zur MühlenHeart Center Freiburg University and Faculty of Medicine, University of Freiburg, Freiburg, Germany. constantin.vonzurmuehlen@universitaets-herzzentrum.de.
University of Freiburg · DEUniversity Hospital of Basel · CHBaker Heart and Diabetes Institute · AUNational Institutes of Health · USUniversity of Virginia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Platelets can be found on the surface of inflamed and ruptured atherosclerotic plaques. Thus, targeting of activated platelets may allow for molecular imaging of vulnerable atherosclerotic lesions. We here investigated microbubbles (MB) functionalized with the selectin ligand sialyl Lewis

Indexed as

MicrobubblesPlatelet ActivationAnimalsAntibodies, ImmobilizedBlood PlateletsCA-19-9 AntigenCarotid ArteriesContrast MediaFemaleLigandsMice, Inbred C57BLOligosaccharidesPlatelet Glycoprotein GPIIb-IIIa ComplexSelectinsThrombosisUltrasonographyAntibodies, ImmobilizedCA-19-9 AntigenContrast MediaLigandsOligosaccharidesPlatelet Glycoprotein GPIIb-IIIa ComplexSelectins

Identifiers

PMID29097799
PMCPMC5668440
OpenAlexW2765257109

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.