ArticleScientific reports2017
Pharmacologically induced reversible hypometabolic state mitigates radiation induced lethality in mice.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Using Organoids to Unlock the Potential of Human Torpor for Spaceflight.Current stem cell reports · 2026Article
- Neurobehavioral Consequences of the 5'-AMP-Induced Torpor-like Hypothermic State.Life (Basel, Switzerland) · 2026Article
- Synthetic torpor: advancing metabolic regulation for medical innovations.Nature metabolism · 2025Review
- Sedative Agents, Synthetic Torpor, and Long-Haul Space Travel-A Systematic Review.Life (Basel, Switzerland) · 2025Review
- Phosphorylation state of Akt in the heart during artificial deep hypothermia in Syrian hamsters.The Journal of veterinary medical science · 2025Article
- Dysfunctional β-cell longevity in diabetes relies on energy conservation and positive epistasis.Life science alliance · 2024Article
- Donepezil Nanoemulsion Induces a Torpor-like State with Reduced Toxicity in NonhibernatingACS nano · 2024Article
- Investigating the effects of chronic low-dose radiation exposure in the liver of a hypothermic zebrafish model.Scientific reports · 2023Article
- Synthetic torpor protects rats from exposure to accelerated heavy ions.Scientific reports · 2022Article
- Unraveling the Big Sleep: Molecular Aspects of Stem Cell Dormancy and Hibernation.Frontiers in physiology · 2021Review
- Metabolic and behavioral features of acute hyperpurinergia and the maternal immune activation mouse model of autism spectrum disorder.PloS one · 2021Article
- Hibernation and Radioprotection: Gene Expression in the Liver and Testicle of Rats Irradiated under Synthetic Torpor.International journal of molecular sciences · 2019Article
- Effects of cold on murine brain mitochondrial function.PloS one · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Therapeutic hypothermia has proven benefits in critical care of a number of diseased states, where inflammation and oxidative stress are the key players. Here, we report that adenosine monophosphate (AMP) triggered hypometabolic state (HMS), 1-3 hours after lethal total body irradiation (TBI) for a duration of 6 hours, rescue mice from radiation-induced lethality and this effect is mediated by the persistent hypothermia. Studies with caffeine and
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.