ArticleNature communications2017
Mammalian γ2 AMPK regulates intrinsic heart rate.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 56 citations in OpenAlex.
- Potential roles of β3-adrenergic receptor in heart rate regulation via sinus node activity and local adipocyte metabolism.The journal of physiological sciences : JPS · 2026Article
- AMPKγ2 Regulates Cardiac Hypertrophy and Arrhythmias via Interacting With Myosin.Circulation research · 2026Article
- AMPK-mediated HCN4 channel phosphorylation contributes to age-related intrinsic bradycardia.The Journal of general physiology · 2026Article
- Promoting differentiation of human-induced pluripotent stem cells into sinoatrial node-like cells through programmed regulation of AMPK signalling pathway.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Article
- Impact of Acute Endurance Exercise on Alternative Splicing in Skeletal Muscle.FASEB bioAdvances · 2025Article
- Maturation of human cardiac organoids enables complex disease modeling and drug discovery.Nature cardiovascular research · 2025Article
- Aging and sinus node dysfunction: mechanisms and future directions.Clinical science (London, England : 1979) · 2025Review
- Impact of Acute Endurance Exercise on Alternative Splicing in Skeletal Muscle.bioRxiv : the preprint server for biology · 2025Article
- Valerenic acid attenuates pathological myocardial hypertrophy by promoting the utilization of multiple substrates in the mitochondrial energy metabolism.Journal of advanced research · 2025Article
- AMPK phosphosite profiling by label-free mass spectrometry reveals a multitude of mTORC1-regulated substrates.npj metabolic health and disease · 2025Article
- AMPK in Intestinal Health and Disease: A Multifaceted Therapeutic Target for Metabolic and Inflammatory Disorders.Drug design, development and therapy · 2025Review
- The metabolic sensor AMPK: Twelve enzymes in one.Molecular metabolism · 2024Review
- AMPKα2 promotes tumor immune escape by inducing CD8+ T-cell exhaustion and CD4+ Treg cell formation in liver hepatocellular carcinoma.BMC cancer · 2024Article
- Refeeding-associated AMPKNature aging · 2023Article
- Emerging Signaling Regulation of Sinoatrial Node Dysfunction.Current cardiology reports · 2023Review
- Hippo Signaling: Advances in Potential Therapeutic Targets for Sinoatrial Node Disorders.International journal of drug discovery and pharmacology · 2023Article
- Hippo-Yap Signaling Maintains Sinoatrial Node Homeostasis.Circulation · 2022Article
- PRKAG2 Cardiomyopathy.Arquivos brasileiros de cardiologia · 2022Article
- Atrial Flutter in PRKAG2 Syndrome: Clinical and Electrophysiological Characteristics.Arquivos brasileiros de cardiologia · 2022Article
- Harnessing conserved signaling and metabolic pathways to enhance the maturation of functional engineered tissues.NPJ Regenerative medicine · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
64 authors at 11 institutions in 6 countries.
Arash YavariExperimental Therapeutics, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK. arash.yavari@well.ox.ac.uk.
Mohamed BellahceneDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Annalisa BucchiDepartment of Biosciences, Università degli Studi di Milano, Milan, 20133, Italy.
Syevda SirenkoLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD, 21224, USA.
Katalin PinterDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Neil HerringBurdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, OX1 3PT, UK.
Julia J JungDepartment of Cardiac Surgery, Rostock University Medical Centre, 18057, Rostock, Germany.
Kirill V TarasovLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD, 21224, USA.ORCID http://orcid.org/0000-0001-7799-4670
Emily J SharpeDepartment of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Markus WolfienDepartment of Systems Biology and Bioinformatics, University of Rostock, Rostock, 18051, Germany.ORCID http://orcid.org/0000-0002-1887-4772
Gabor CzibikDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Violetta SteeplesDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Sahar GhaffariDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Chinh NguyenDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Alexander StockenhuberDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Joshua R St ClairDepartment of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Christian RimmbachDepartment of Cardiac Surgery, Rostock University Medical Centre, 18057, Rostock, Germany.
Yosuke OkamotoLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD, 21224, USA.
Dongmei YangLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD, 21224, USA.
Mingyi WangLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD, 21224, USA.
Bruce D ZimanLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD, 21224, USA.
Jack M MoenLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD, 21224, USA.
Daniel R RiordonLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD, 21224, USA.
Christopher RamirezLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD, 21224, USA.
Manuel PainaDepartment of Biosciences, Università degli Studi di Milano, Milan, 20133, Italy.
Joonho LeeLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD, 21224, USA.
Jing ZhangLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD, 21224, USA.
Ismayil AhmetLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD, 21224, USA.
Michael G MattLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD, 21224, USA.
Yelena S TarasovaLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD, 21224, USA.
Dilair BabanThe Wellcome Trust Centre for Human Genetics, Oxford, OX3 7BN, UK.
Natasha SahgalThe Wellcome Trust Centre for Human Genetics, Oxford, OX3 7BN, UK.
Helen LockstoneThe Wellcome Trust Centre for Human Genetics, Oxford, OX3 7BN, UK.
Rathi PuliyadiDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Joseph de BonoDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Owen M SiggsThe Wellcome Trust Centre for Human Genetics, Oxford, OX3 7BN, UK.ORCID http://orcid.org/0000-0003-2840-4851
John GomesDepartment of Medicine, BHF Laboratories, The Rayne Institute, University College London, London, WC1E 6JJ, UK.
Hannah MuskettDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Mahon L MaguireDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Youlia BeglovDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Matthew KellyDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Pedro P N Dos SantosInstituto de Pós-Graduação, Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, 30.130-110, Brazil.
Nicola J BrightCellular Stress Group, MRC London Institute of Medical Sciences, Imperial College London, London, W12 0NN, UK.
Angela WoodsCellular Stress Group, MRC London Institute of Medical Sciences, Imperial College London, London, W12 0NN, UK.
Katja GehmlichDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.ORCID http://orcid.org/0000-0003-4019-1844
Henrik IsacksonDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Gillian DouglasDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
David J P FergusonNuffield Department of Clinical Laboratory Science, University of Oxford, Oxford, OX3 9DU, UK.ORCID http://orcid.org/0000-0001-5045-819X
Jürgen E SchneiderDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.ORCID http://orcid.org/0000-0003-0999-5684
Andrew TinkerDepartment of Medicine, BHF Laboratories, The Rayne Institute, University College London, London, WC1E 6JJ, UK.
Olaf WolkenhauerDepartment of Systems Biology and Bioinformatics, University of Rostock, Rostock, 18051, Germany.
Keith M ChannonDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Richard J CornallThe Wellcome Trust Centre for Human Genetics, Oxford, OX3 7BN, UK.
Eduardo B SternickInstituto de Pós-Graduação, Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, 30.130-110, Brazil.
David J PatersonBurdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford, OX1 3PT, UK.
Charles S RedwoodDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
David CarlingCellular Stress Group, MRC London Institute of Medical Sciences, Imperial College London, London, W12 0NN, UK.
Catherine ProenzaDepartment of Physiology and Biophysics, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Robert DavidDepartment of Cardiac Surgery, Rostock University Medical Centre, 18057, Rostock, Germany.
Mirko BaruscottiDepartment of Biosciences, Università degli Studi di Milano, Milan, 20133, Italy.
Dario DiFrancescoDepartment of Biosciences, Università degli Studi di Milano, Milan, 20133, Italy.ORCID http://orcid.org/0000-0002-7322-1790
Edward G LakattaLaboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, NIH, Baltimore, MD, 21224, USA.
Hugh WatkinsDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Houman AshrafianExperimental Therapeutics, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK. houman.ashrafian@cardiov.ox.ac.uk.
Centre for Human Genetics · GBNational Institute on Aging · USUniversity of Oxford · GBUniversity of Milan · ITUniversity of Rostock · DEMRC London Institute of Medical Sciences · GBUniversity of Colorado Denver · USFaculdade de Ciências Médicas de Minas Gerais · BRStellenbosch University · ZAUniversity College London · GBWilliam Harvey Research Institute · GB
Funding
Regulation of excitability in sinoatrial myocytesR01HL088427 · NHLBI · UNIVERSITY OF CONNECTICUT STORRS · PI PROENZA, CATHERINE · 2008 to 2024
$5.8MBritish Heart Foundation FS/11/50/29038British Heart Foundation FS/12/40/29712British Heart Foundation FS/15/8/31155British Heart Foundation PG/14/41/30877British Heart Foundation RG/07/003/23133British Heart Foundation RG/07/012/24110British Heart Foundation RG/12/16/29939British Heart Foundation RG/12/5/29576British Heart Foundation RG/17/10/32859Medical Research Council G0200482Medical Research Council G0600829Medical Research Council MC_U120027537Medical Research Council MC_UU_00008/6Medical Research Council MC_UU_12010/6NHLBI NIH HHS R01 HL088427Wellcome Trust 086632/Z/08/Z
Abstract
AMPK is a conserved serine/threonine kinase whose activity maintains cellular energy homeostasis. Eukaryotic AMPK exists as αβγ complexes, whose regulatory γ subunit confers energy sensor function by binding adenine nucleotides. Humans bearing activating mutations in the γ2 subunit exhibit a phenotype including unexplained slowing of heart rate (bradycardia). Here, we show that γ2 AMPK activation downregulates fundamental sinoatrial cell pacemaker mechanisms to lower heart rate, including sarcolemmal hyperpolarization-activated current (I
Indexed as
AdultAMP-Activated Protein KinasesAnimalsBradycardiaCalciumElectrocardiography, AmbulatoryExerciseHeartHeart RateHumansMagnetic Resonance Imaging, CineMagnetic Resonance SpectroscopyMiceMicroscopy, Electron, TransmissionMutationMyocardiumAMP-Activated Protein KinasesCalciumPRKAG2 protein, humanRyanodine Receptor Calcium Release Channel
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.